Estimation of Current and Future Physiological States in Insular Cortex
Estimation of Current and Future Physiological States in Insular Cortex
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DOI：
10.1016/j.neuron.2019.12.027
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发表时间：
2020-03-18
期刊：
影响因子：
16.2
通讯作者：
Andermann, Mark L.
中科院分区：
文献类型：
--
作者：
Livneh, Yoav;Sugden, Arthur U.;Andermann, Mark L.
内感受，即对身体内部信号的感觉，对于生理稳态、认知和情感是必不可少的。虽然人类岛叶皮层（InsCtx）参与内感受，但细胞和回路机制仍不清楚。我们在两种生理缺陷状态下对小鼠InsCtx神经元进行成像：饥饿和口渴。InsCtx持续的活动模式可靠地跟踪逐渐恢复稳态，但不改变行为。因此，虽然通过激活特定的下丘脑神经元（AgRP或SFOGLUT）在饱足小鼠中人工诱导饥饿或口渴恢复了线索诱发的食物或水寻找，但InsCtx持续活动继续反映生理饱足感。在自然饥饿或口渴期间，食物或水线索迅速且短暂地将InsCtx群体活动转移到未来的饱腹感相关模式。在人工饥饿或口渴期间，食物或水的线索进一步改变了当前与饱腹感相关的模式之外的活动。再加上电路映射实验，这些发现表明InsCtx将当前生理状态的内脏感觉信号与下丘脑门控杏仁核输入相结合，这些输入发出即将摄入食物或水的信号，以计算对未来生理状态的预测。
Interoception, the sense of internal bodily signals, is essential for physiological homeostasis, cognition, and emotions. While human insular cortex (InsCtx) is implicated in interoception, the cellular and circuit mechanisms remain unclear. We imaged mouse InsCtx neurons during two physiological deficiency states: hunger and thirst. InsCtx ongoing activity patterns reliably tracked the gradual return to homeostasis but not changes in behavior. Accordingly, while artificial induction of hunger or thirst in sated mice via activation of specific hypothalamic neurons (AgRP or SFOGLUT) restored cue-evoked food- or water-seeking, InsCtx ongoing activity continued to reflect physiological satiety. During natural hunger or thirst, food or water cues rapidly and transiently shifted InsCtx population activity to the future satiety-related pattern. During artificial hunger or thirst, food or water cues further shifted activity beyond the current satiety-related pattern. Together with circuit-mapping experiments, these findings suggest that InsCtx integrates visceral-sensory signals of current physiological state with hypothalamus-gated amygdala inputs that signal upcoming ingestion of food or water to compute a prediction of future physiological state.