Genetic control of immunity to parasites. Infection with Trichinella spiralis in inbred and congenic mice showing rapid and slow responses to infection
Genetic control of immunity to parasites. Infection with Trichinella spiralis in inbred and congenic mice showing rapid and slow responses to infection
复制标题
对寄生虫的免疫力的遗传控制。
DOI：
10.1111/j.1365-3024.1980.tb00045.x
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发表时间：
1980
影响因子：
2.2
通讯作者：
D. Wakelin
中科院分区：
文献类型：
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作者：
D. Wakelin
近交系小鼠对旋毛虫感染反应的品系差异反映在成虫的存活长度、繁殖力和获得肌肉幼虫的数量上。3株菌株NIH、SWR和DBA1（均为H2q）反应迅速，在12 d内排出大部分成虫，肌肉幼虫负荷相对较低。B10小鼠（H2b）和5个相关菌株(B10；G (H2q) B10。BR (H2k), B10。AKM (H2d), B10。AKM （H2m）和B10。T(6R) （H2y2）反应缓慢，保留成人超过12天，并获得沉重的肌肉负担。B10小鼠的缓慢反应在老年和年轻小鼠，原发性和继发性感染中都很明显，并且作为隐性特征遗传。没有证据表明反应缓慢是由抑制细胞活性引起的。这些结果讨论了位于主要组织相容性复合体内部和外部的基因的影响。
Summary Strain variation in the response of inbred mice to infection with Trichinella spiralis was reflected in the length of survival of the adult worms, their fecundity and in the number of muscle larvae acquired. Three strains, NIH, SWR and DBA1 (all H2q), responded rapidly, expelled most of the adult worms within 12 days and had relatively low burdens of muscle larvae. B10 mice (H2b) and five related strains (B10.G (H2q), B10.BR (H2k), B10.AKM (H2d), B10.AKM (H2m) and B10.T(6R) (H2y2)) responded slowly, retaining adults for more than 12 days and acquiring heavy muscle burdens. The slow response of B10 mice was evident in both old and young mice, in primary and secondary infections and was inherited as a recessive characteristic. No evidence was obtained that slow responsiveness resulted from suppressor cell activity. The results are discussed in relation to the influence of genes located within and without the major histocompatibility complex.