Correlates of respiratory cycle-related EEG changes in children with sleep-disordered breathing
Correlates of respiratory cycle-related EEG changes in children with sleep-disordered breathing
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DOI：
10.1093/sleep/27.1.116
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发表时间：
2004-02-01
期刊：
影响因子：
5.6
通讯作者：
Ruzicka, DL
中科院分区：
文献类型：
--
作者：
Chervin, RD;Burns, JW;Ruzicka, DL
研究目的：探索新发现的呼吸周期相关脑电图变化（RCREC），它可能代表微觉醒，作为睡眠呼吸障碍（SDB）儿童神经行为结果的相关因素。设计：回顾性。设置：大学睡眠实验室。参与者：10名研究受试者，年龄6至10岁，有或无SDB。干预：多导睡眠图、多次睡眠潜伏期测试和在临床指征性扁桃体切除术（n 9）或疝修补术前后的听觉注意力测试（n = 1，对照）测量：对于夜间睡眠的前3个小时，计算机算法量化δ、θ和α脑电图功率在非呼吸暂停呼吸周期内变化的程度。RCREC和SDB，嗜睡和注意力的标准客观措施之间的相关性进行了探讨。结果：5名儿童患有SDB（每小时睡眠> 1次阻塞性呼吸暂停）。除1例无SDB和1例对照外，所有受试者的术前δ、θ或α RCREC均具有统计学显著性（P <0.01）。Theta RCREC与呼吸暂停和呼吸不足的发生率相关（P = 0.01），并且在呼吸暂停治疗后下降。术后δ和θ RCREC的变化预测了多次睡眠潜伏期测试评分的变化（rho =-0.84，P = 0.002; rho =-0.64，P = 0.05），而呼吸暂停和呼吸不足发生率的变化则没有预测（rho =-0.24，P = 0.50）。术后注意力的变化与δ RCREC的变化（rho =-0.54，P = .11）的相关性比与呼吸暂停事件发生率的变化（rho =-0.07，P = .84）的相关性更强。结论：RCREC可能反映了短暂但大量的微觉醒，有助于解释SDB的神经行为后果。
Study Objectives: To explore newly-identified respiratory cycle-related electroencephalographic changes (RCREC), which may represent microarousals, as correlates of neurobehavioral outcomes in children with sleep-disordered breathing (SDB).Design: Retrospective.Setting: University sleep laboratory.Participants: Ten research subjects, aged 6 to 10 years, with and without SDB.Intervention: Polysomnography, Multiple Sleep Latency Tests, and tests of auditory attention before and after clinically-indicated tonsillectomy (n 9) or hernia repair (n = 1, control).Measurements: For the first 3 hours of nocturnal sleep, a computer algorithm quantified the degree to which delta, theta, and alpha electroencephalographic power varied within non-apneic respiratory cycles. Correlations between the RCREC and standard objective measures of SDB, sleepiness, and attention were explored. Results: Five children had SDB (> 1 obstructive apnea per hour of sleep). Preoperative delta, theta, or alpha RCREC were statistically significant (P < .01) in all subjects except 1 without SDB and the 1 control. Theta RCREC correlated with rates of apneas and hypopneas (P = .01) and decreased after the apnea was treated. Postoperative changes in delta and theta RCREC predicted changes in Multiple Sleep Latency Test scores (rho = -0.84, P = .002; rho = -0.64, P = .05), whereas changes in rates of apneas and hypopneas did not (rho = -0.24, P = .50). Postoperative changes in attention tended to correlate with changes in delta RCREC (rho = -0.54, P = .11) more strongly than with changes in rates of apneic events (rho = -0.07, P = .84).Conclusions: The RCREC may reflect brief but numerous microarousals that could help to explain neurobehavioral consequences of SDB.