Associations of physical activity and inactivity before and during pregnancy with glucose tolerance
Associations of physical activity and inactivity before and during pregnancy with glucose tolerance
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DOI：
10.1097/01.aog.0000241088.60745.70
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发表时间：
2006-11-01
影响因子：
7.2
通讯作者：
Gillman, Matthew W.
中科院分区：
文献类型：
--
作者：
Oken, Emily;Ning, Yi;Gillman, Matthew W.
目的：研究孕前和孕期体力活动和看电视与妊娠期糖尿病（GDM）和糖耐量异常的风险之间的关系，以及GDM与不太严重的糖耐量受损的组合。我们评估了参加Viva项目的1,805名妇女在怀孕前和怀孕期间体力活动的持续时间和强度以及看电视的时间，一项在东马萨诸塞州进行的队列研究。根据临床糖耐量试验结果，我们确定了1，493名（83%）葡萄糖耐量正常的妇女和312名（17%）葡萄糖耐量异常的妇女，其中包括91名（5%）GDM。在调整年龄、种族或民族、GDM史、糖尿病家族史和孕前体重指数后，我们的数据表明，在怀孕前一年从事任何剧烈体力活动的妇女患GDM的风险降低（比值比[OR] 0.56，95%可信区间[CI] 0.330.95）与糖耐量异常（OR 0.76，95% CI 0.57-1.00）相关。报告妊娠前剧烈活动和妊娠期间轻度至中度或剧烈活动的女性与报告这些活动的女性相比，GDM（OR 0.49，95% CI 0.24-1.01）和糖耐量异常（OR 0.70，95% CI 0.49-1.01）的风险似乎较低。步行和总体力活动提供了适度的好处。我们观察到没有关联的电视观看前或怀孕期间与GDM或异常glucose tolerance.CONCLUSION的风险：体力活动，特别是剧烈活动在怀孕前，至少轻至中度活动在怀孕期间，可能会降低糖耐量异常和GDM的风险。
OBJECTIVE: To investigate associations of physical activity and television viewing before and during pregnancy with risk of gestational diabetes mellitus (GDM) and abnormal glucose tolerance, the combination of GDM with less severe impaired glucose tolerance.METHODS: We assessed duration and intensity of physical activity and time spent viewing television both before and during pregnancy among 1,805 women enrolled in Project Viva, a cohort study in eastern Massachusetts. We identified 1,493 (83%) women with normal glucose tolerance and 312 (17%) with abnormal glucose tolerance, including 91 (5%) with GDM based on clinical glucose tolerance test results.RESULTS: After adjustment for age, race or ethnicity, history of GDM, family history of diabetes, and prepregnancy body mass index, our data suggest that women who engaged in any vigorous physical activity in the year before pregnancy experienced a reduced risk of GDM (odds ratio [OR] 0.56, 95% confidence interval [CI] 0.330.95) and abnormal glucose tolerance (OR 0.76, 95% CI 0.57-1.00). Women who reported vigorous activity before pregnancy and light-to-moderate or vigorous activity during pregnancy appeared to have a lower risk of both GDM (OR 0.49, 95% CI 0.24-1.01) and abnormal glucose tolerance (OR 0.70, 95% CI 0.49-1.01) compared with women reporting these activities in neither time period. Walking and total physical activity provided modest benefits. We observed no association of television viewing before or during pregnancy with risk of GDM or abnormal glucose tolerance.CONCLUSION: Physical activity, especially vigorous activity before pregnancy and at least light-to-moderate activity during pregnancy, may reduce risk for abnormal glucose tolerance and GDM.