Heritability of diurnal type:: a nationwide study of 8753 adult twin pairs
Heritability of diurnal type:: a nationwide study of 8753 adult twin pairs
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DOI：
10.1111/j.1365-2869.2007.00580.x
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发表时间：
2007-06-01
影响因子：
4.4
通讯作者：
Kaprio, Jaakko
中科院分区：
文献类型：
--
作者：
Koskenvuo, Markku;Hublin, Christer;Kaprio, Jaakko
双胞胎研究表明，在昼夜类型的遗传成分。在1981年，一份问卷发送到老年芬兰双胞胎队列产生的答复，从2836成人同卵（MZ）和5917同性异卵（DZ）双胞胎对四类自我报告的昼夜类型。我们使用结构方程模型来估计遗传和环境成分的方差在morningness和eveningness。当早晨和晚上同时分析时，模型拟合最好。ADE模型（包括加性遗传，显性遗传和非共享环境效应）拟合最好的数据。男性和女性的ADE模型与组合模型在统计学上没有显著差异，同样，年轻和老年组的ADE模型也没有差异。总体遗传效应（广义遗传力）的估计值为49.7%（95%置信区间为46.4-52.8），其余由兄弟姐妹不共享的环境因素引起。加性遗传因素和显性遗传因素对昼型的潜在影响的方差分量估计值分别为11.7%（95%CI 0-23.7）和38.0%（24.7-51.3）。因此，遗传效应约占一半的个体间变异的昼夜型成人。
Twin studies suggest a genetic component in diurnal types. In 1981, a questionnaire sent to the Older Finnish Twin Cohort yielded responses from 2836 adult monozygotic (MZ) and 5917 like-sexed dizygotic (DZ) twin pairs with four category self-report on diurnal type. We used structural equation modelling to estimate genetic and environmental components of variance in morningness and eveningness. The model fitting was best when the morningness and the eveningness were analysed together. The ADE-model (including additive genetic, dominant genetic and non-shared environmental effects) fitted best to the data. ADE-models for men and women separately did not differ in a statistically significant manner from the combined model, and similarly ADE-models for young and old age groups separately did not differ either. The estimate for overall genetic effect (broad sense heritability) was 49.7% (95% confidence interval 46.4-52.8), with the remainder accounted for by environmental factors not shared by siblings. The variance component estimates for the underlying liability to diurnal type were 11.7% (95% CI 0-23.7) for additive genetic factors, 38.0% (24.7-51.3) for genetic factors due to dominance. Genetic effects thus account for about one-half of the interindividual variability in diurnal type in adults.