Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
Nonvascular VEGF receptor 3 expression by corneal epithelium maintains avascularity and vision
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DOI：
10.1073/pnas.0506112103
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发表时间：
2006-07-25
影响因子：
11.1
通讯作者：
Dana, Reza
中科院分区：
文献类型：
--
作者：
Cursiefen, Claus;Chen, Lu;Dana, Reza
角膜是眼睛的窗口，透明是视力的先决条件。血管新生进入正常无血管的角膜与良好的视力是不相容的，因此，角膜是人体中少数几个主动维持无血管的组织之一。在这里，我们提供证据的关键机制有助于角膜血管。VEGF受体3通常存在于淋巴和增殖血管内皮上，在角膜上皮中具有强组成性表达，并在机制上负责抑制炎症性角膜血管生成。
Transparency of the cornea, the window of the eye, is a prerequisite for vision. Angiogenesis into the normally avascular cornea is incompatible with good vision and, therefore, the cornea is one of the few tissues in the human body where avascularity is actively maintained. Here, we provide evidence for a critical mechanism contributing to corneal avascularity. VEGF receptor 3, normally present on lymphatic and proliferating blood vascular endothelium, is strongly constitutively expressed by corneal epithelium and is mechanistically responsible for suppressing inflammatory corneal angiogenesis.