Studies on the total synthesis of (-)-CP-263,114.

Studies on the total synthesis of (-)-CP-263,114.
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DOI：
10.1021/jo048681u
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发表时间：
2004-11
期刊：
The Journal of organic chemistry
影响因子：
--
通讯作者：
T. Yoshimitsu;Shuji Sasaki;Y. Arano;H. Nagaoka
T. Yoshimitsu;Shuji Sasaki;Y. Arano;H. Nagaoka
中科院分区：
其他
文献类型：
--
作者：
T. Yoshimitsu;Shuji Sasaki;Y. Arano;H. Nagaoka

文献摘要

相似文献

烷氧基在分子转化中具有显著的化学性质，在有机合成中有着广泛的应用。本研究表明，两种类型的烷氧基(伯基和叔基)选择性地经历脱氢和β断裂，从而产生(-)-CP-263,114(1)的关键结构元素。通过烷氧基转化，然后安装C19-C25(CP编号)侧链和桥联双缩醛单元，得到官能化的CP前驱体2。
Alkoxyl radicals have a wide range of applications in organic synthesis due to their remarkable chemical properties in molecular transformation. The present study shows two types of alkoxyl radicals (primary vs tertiary) to selectively undergo dehydrogenation and beta-scission to give rise to key structural elements of (-)-CP-263,114 (1). By alkoxyl radical transformation followed by installation of the C19-C25 (CP numbering) side chain and the bridged bisacetal unit, the functionalized CP precursor 2 was obtained.