Renal manifestations of the antiphospholipid syndrome
Renal manifestations of the antiphospholipid syndrome
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DOI：
10.1191/0961203305lu2058oa
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发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
D'Cruz, DP
中科院分区：
文献类型：
--
作者：
D'Cruz, DP
自抗磷脂（休斯）综合征（APS）的最早描述以来，就有肾血栓形成表现的报道。抗磷脂肾病相关的临床特征谱继续扩大。本文将重点介绍近年来的进展，如高血压的患病率，青斑和肾动脉狭窄，以及超微结构的变化，在抗磷脂肾病。抗磷脂抗体阳性患者肾移植的风险增加也进行了讨论，导致一些作者质疑这些患者是否应该接受移植。
Renal thrombotic manifestations have been reported since the earliest descriptions of the antiphospholipid (Hughes) syndrome (APS). The spectrum of clinical features associated with antiphospholipid nephropathy continues to widen. This review will highlight recent developments such as the prevalence of hypertension, livedo reticularis and renal artery stenosis as well as the ultrastructural changes seen in antiphospholipid nephropathy. The increasing risks of renal transplantation in antiphospholipid antibody positive patients is also discussed leading some authors to question whether these patients should undergo transplantation at all.