The Developmental Origins, Mechanisms, and Implications of Metabolic Syndrome
The Developmental Origins, Mechanisms, and Implications of Metabolic Syndrome
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DOI：
10.3945/jn.109.111179
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发表时间：
2010-03-01
影响因子：
4.2
通讯作者：
Hanson, Mark A.
中科院分区：
文献类型：
--
作者：
Bruce, Kimberley D.;Hanson, Mark A.
代谢综合征（MetS）代表心脏代谢风险决定因素的组合，包括向心性肥胖、胰岛素抵抗、葡萄糖耐受不良、血脂异常、高血压、高胰岛素血症和微量白蛋白尿。代谢综合征的患病率在世界范围内迅速增加，主要是由于持续的肥胖流行。在发育早期的环境因素已被证明会影响在以后的生活中发展疾病的易感性。特别是，有大量的证据，从流行病学和动物研究的MetS的功能，由于不平衡的孕产妇营养的发病率更高。营养损伤在发育可塑性期间导致MetS表型的机制现在开始受到相当大的科学兴趣。本文综述了最近的数据有关这些机制，特别是表观遗传和转录调控的关键代谢基因在营养刺激介导的持续变化和成人代谢综合征表型。对这些机制的持续和更深入的了解最终将允许特定的干预措施，对未来心血管疾病和2型糖尿病的全球发病率产生有利影响。J.营养140：648-652，2010.
Metabolic syndrome (MetS) represents a combination of cardio-metabolic risk determinants, including central obesity, insulin resistance, glucose intolerance, dyslipidemia, hypertension, hyperinsulinemia, and microalbuminuria. The prevalence of MetS is rapidly increasing worldwide, largely as a consequence of the ongoing obesity epidemic. Environmental factors during periods early in development have been shown to influence the susceptibility to develop disease in later life. In particular, there is a wealth of evidence from both epidemiological and animal studies for greater incidence of features of MetS as a result of unbalanced maternal nutrition. The mechanisms by which nutritional insults during a period of developmental plasticity result in a MetS phenotype are now beginning to receive considerable scientific interest. This review focuses on recent data regarding these mechanisms, in particular the epigenetic and transcriptional regulation of key metabolic genes in response to nutritional stimuli that mediate persistent changes and an adult MetS phenotype. A continued and greater understanding of these mechanisms will eventually allow specific interventions, with a favorable impact on the global incidence of cardiovascular disease and type 2 diabetes in the future. J. Nutr. 140: 648-652, 2010.