Use of suramin in treatment of prostatic carcinoma refractory to conventional hormonal manipulation.
Use of suramin in treatment of prostatic carcinoma refractory to conventional hormonal manipulation.
复制标题
苏拉明在治疗传统激素操作难治性前列腺癌中的用途。
DOI：
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发表时间：
1991
影响因子：
2.4
通讯作者：
C. Myers
中科院分区：
文献类型：
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作者：
R. Larocca;M. Cooper;M. Uhrich;R. Danesi;M. Walther;W. Linehan;C. Myers
苏拉明和相关化合物，鉴于其生长因子和酶结合特性，在许多方面代表了治疗癌症的新方法。虽然在苏拉明用于治疗转移性前列腺癌的初步分析中，客观反应率似乎并不令人印象深刻，但仍需要做大量工作来优化苏拉明对患者的给药，并阐明其各种假定的作用机制。具有更特异性酶和生长因子拮抗剂特性的相关化合物的开发正在进行中。
Suramin and related compounds, in view of their growth factor and enzyme binding properties, represent in many respects a novel approach to the treatment of cancer. Although in this preliminary analysis of suramin use in the treatment of metastatic prostate cancer, the objective response rate does not appear impressive, much work still needs to be done to optimize suramin's administration to patients and to elucidate its various postulated mechanisms of action. The development of related compounds with more specific enzyme and growth factor antagonist properties is under way.