Functional brain abnormalities associated with comorbid anxiety in autism spectrum disorder.
Functional brain abnormalities associated with comorbid anxiety in autism spectrum disorder.
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DOI：
10.1017/s0954579420000772
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发表时间：
2020-10
影响因子：
3.3
通讯作者：
Mosconi MW
中科院分区：
文献类型：
--
作者：
Bartolotti J;Sweeney JA;Mosconi MW
焦虑症在自闭症谱系障碍（ASD）中很常见，并与社交沟通和重复行为症状有关。ASD中焦虑的神经生物学尚不清楚，但杏仁核功能障碍与ASD和焦虑症有关。使用静息态fMRI，我们比较了在自闭症脑成像数据交换（ABIDE）中研究的三个人口统计学匹配组的杏仁核-前额叶和杏仁核-纹状体连接：ASD伴焦虑障碍（N = 25; ASD+焦虑），ASD无共病障碍（N = 68; ASD−NoAnx）和典型发展对照（N = 139; TD）。相对于ASD−NoAnx和TD对照组，ASD+焦虑个体的杏仁核和背侧/喙侧前扣带回（dACC和rACC）之间的连接减少。这些连接的功能连接在ASD−NoAnx中没有受到影响，并且杏仁核与腹侧ACC/mPFC回路的连接在ASD+焦虑或ASD−NoAnx中与TD没有差异。杏仁核-dmPFC/rACC连接性降低与ASD+焦虑症患者更严重的社会障碍相关;杏仁核-纹状体连接性与ASD−NoAnx患者的RRB症状严重程度相关。这些研究结果表明，ASD中的共病焦虑与杏仁核背侧ACC/mPFC通路支持的情绪监测过程中断有关，而涉及杏仁核-vmPFC的情绪调节系统相对较少。我们的结果强调了考虑共病焦虑对于解析ASD神经生物学异质性的重要性。
Anxiety disorders are common in autism spectrum disorder (ASD) and associated with social-communication and repetitive behavior symptoms. The neurobiology of anxiety in ASD is unknown, but amygdala dysfunction has been implicated in both ASD and anxiety disorders. Using resting-state fMRI, we compared amygdala-prefrontal and amygdala-striatal connections across three demographically matched groups studied in the Autism Brain Imaging Data Exchange (ABIDE): ASD with a comorbid anxiety disorder (N = 25; ASD+Anxiety), ASD without a comorbid disorder (N = 68; ASD−NoAnx), and typically developing controls (N = 139; TD). Relative to ASD−NoAnx and TD controls, ASD+Anxiety individuals had decreased connectivity between amygdala and dorsal/rostral anterior cingulate (dACC and rACC). Functional connectivity of these connections was not affected in ASD−NoAnx, and amygdala connectivity with ventral ACC/mPFC circuits was not different in ASD+Anxiety or ASD−NoAnx relative to TD. Decreased amygdala-dmPFC/rACC connectivity was associated with more severe social impairment in ASD+Anxiety; amygdala-striatal connectivity was associated with RRB symptom severity in ASD−NoAnx individuals. These findings suggest comorbid anxiety in ASD is associated with disrupted emotion monitoring processes supported by amygdala-dorsal ACC/mPFC pathways, whereas emotion regulation systems involving amygdala-vmPFC are relatively spared. Our results highlight the importance of accounting for comorbid anxiety for parsing ASD neurobiological heterogeneity.