Functional regulation of FoxO1 in neural stem cell differentiation
Functional regulation of FoxO1 in neural stem cell differentiation
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DOI：
10.1038/cdd.2015.123
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发表时间：
2015-12-01
影响因子：
12.4
通讯作者：
Paik, J-H
中科院分区：
文献类型：
--
作者：
Kim, D-Y;Hwang, I.;Paik, J-H
Forkhead转录因子家族O(FoxO)通过支持成体干细胞的长期增殖能力来维持其储备。在神经发育过程中，microRNAs(MiRs)通过调控一组特定靶基因的表达来调控神经干/祖细胞的增殖和分化。在神经源性脑室下区，FoxO1在NSPC中特异表达，在向神经母细胞阶段的转变中不再检测到，与miR-9的表达呈负相关。FoxO1的3‘非翻译区含有一个保守的miR-9靶序列，在神经元分化过程中，FoxO1与miR-9的表达是协调的。我们的研究表明，FoxO1通过与Notch信号通路的合作参与了NSPC的命运决定。
Forkhead transcription factor family O (FoxO) maintains adult stem cell reserves by supporting their long-term proliferative potential. MicroRNAs (miRs) regulate neuronal stem/progenitor cell (NSPC) proliferation and differentiation during neural development by controlling the expression of a specific set of target genes. In the neurogenic subventricular zone, FoxO1 is specifically expressed in NSPCs and is no longer detected during the transition to neuroblast stage, forming an inverse correlation with miR-9 expression. The 3'-untranslated region of FoxO1 contains a conserved target sequence of miR-9 and FoxO1 expression is coordinated in concert with miR-9 during neuronal differentiation. Our study demonstrates that FoxO1 contributes to NSPC fate decision through its cooperation with the Notch signaling pathway.