White Matter Integrity Disruptions Correlate With Cognitive Impairments in Asthma
White Matter Integrity Disruptions Correlate With Cognitive Impairments in Asthma
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白质完整性破坏与哮喘认知障碍相关
DOI：
10.1002/jmri.25946
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发表时间：
2018-09-01
影响因子：
4.4
通讯作者：
Yuan, Yonggui
中科院分区：
文献类型：
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作者：
Bian, Rongrong;Zhang, Yuqun;Yuan, Yonggui
背景：哮喘是一种严重的全球性健康问题，以慢性气道炎症为特征，认知功能障碍在哮喘中很常见。目的/假设：探讨哮喘认知功能障碍的神经机制。我们假设哮喘患者表现出改变的白色物质（WM）微结构，这可能导致他们的认知障碍。研究类型：病例对照研究。受试者：37名哮喘患者（14名男性）和31名健康对照（10名男性）。场强/序列：在3.0T扫描仪上使用单次激发回波平面成像序列获得覆盖全脑的扩散张量成像（DTI）。采用DTI技术结合基于束的空间统计学（Tract-based Spatial Statistics，TBSS）方法，对脑白质各向异性分数（WM fractional anisotropy，FA）值的全脑差异进行研究。结果：哮喘患者存在语言能力、执行功能和视觉空间加工的损害以及广泛的由FA减少反映的WM中断。执行功能与左侧大钳、扣带回、右侧钩束、下纵束呈正相关（P < 0.05）。FA异常与哮喘持续时间和哮喘控制测试（ACT）scores.Data呈正相关结论：哮喘患者表现出多种认知功能障碍和普遍的WM完整性中断，其中执行功能障碍与WM异常密切相关。证据等级：1技术有效性：第5阶段
Background: Cognitive impairments are common in asthma, which is a serious global health problem characterized by chronic airway inflammation. However, the underlying neuromechanism is still unclear.Purpose/Hypothesis: To investigate the neuromechanism underlying cognitive impairments of asthma. We hypothesized that asthma patients exhibit altered white matter (WM) microstructures, which may contribute to their cognitive impairments.Study Type: Case-control study.Subjects: 37 patients with asthma (14 male) and 31 healthy controls (10 male).Field Strength/Sequence: Diffusion tensor imaging (DTI) covering the whole brain was acquired on a 3.0T scanner using a single-shot echo planar imaging sequence.Assessment: A DTI with tract-based spatial statistics (TBSS) approach was used to investigate the whole-brain differences in the WM fractional anisotropy (FA) values.Statistical Tests: Demographic and neuropsychological data were performed using two independent sample t-test or chi-square test or Mann-Whitney rank test. The relationship between cognitive impairments and WM abnormalities was studied using correlation analyses.Results: Impairments of language ability, executive function, and visual-spatial processing and widespread WM disruptions reflected by FA reduction were found in asthma patients. The executive function was related to left forceps major, cingulum, and right uncinate fasciculus, ILF (inferior longitudinal fasciculus) positively (P < 0.05). FA abnormalities were positively correlated with duration of asthma and asthma control test (ACT) scores.Data Conclusion: Asthma patients display multiple cognitive impairments and universally WM integrity disruptions, among which executive dysfunction closely correlates with WM abnormalities. Level of Evidence: 1 Technical Efficacy: Stage 5