Regulation of the intercellular adhesin locus regulator (icaR) by SarA, σB, and IcaR in Staphylococcus aureus
Regulation of the intercellular adhesin locus regulator (icaR) by SarA, σB, and IcaR in Staphylococcus aureus
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DOI：
10.1128/jb.00482-08
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发表时间：
2008-10-01
影响因子：
3.2
通讯作者：
Jefferson, Kimberly K.
中科院分区：
文献类型：
--
作者：
Cerca, Nuno;Brooks, Jamie L.;Jefferson, Kimberly K.
葡萄球菌附属调节因子SarA和可变西格玛因子西格玛（B）先前已被确定为icaADBC表达的正调节因子，而IcaR是其负调节因子。在此，我们表明在金黄色葡萄球菌中，SarA和西格玛（B）对icaR表达也是必需的，并且IcaR对其自身表达没有显著影响。
The staphylococcal accessory regulator SarA and the alternative sigma factor sigma(B) have been previously identified as positive regulators, and IcaR as a negative regulator, of icaADBC expression. Here, we show that in Staphylococcus aureus SarA and sigma(B) are also required for icaR expression and that IcaR does not have a significant effect on its own expression.