Beta-endorphin modulates human immune activity via non-opiate receptor mechanisms.
Beta-endorphin modulates human immune activity via non-opiate receptor mechanisms.
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β-内啡肽通过非阿片受体机制调节人体免疫活性。
DOI：
10.1016/0024-3205(82)90054-6
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发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
J. Grbic
中科院分区：
文献类型：
--
作者：
H. W. McCain;Ira B. Lamster;J. Bozzone;J. Grbic
在这里，我们报告说，B-内啡肽是一个强大的和有效的抑制植物血凝素诱导的T淋巴细胞胚细胞时，人白细胞暴露在有丝分裂激活过程中的早期。然而，如果通过预先暴露于有丝分裂原而建立胚细胞发生，则这种抑制变得更难观察。用阿片拮抗剂纳洛酮预处理不能阻断B-内啡肽的抑制作用。因此，这些结果表明，人类免疫表达的神经内分泌调节可能是由不同于传统阿片受体的机制介导的B-内啡肽的外周生理功能。
Here we report that B-endorphin is a potent and efficacious suppressor of phytohemagglutinin induced T-lymphocyte blastogenesis when human leukocytes are exposed early in the course of mitogenic activation. This suppression becomes more difficult to observe, however, if blastogenesis is established by prior exposure to mitogen. Suppression by B-endorphin is not blocked by pretreatment with the opiate antagonist naloxone. These results, therefore, suggest that neuroendocrine modulation of human immune expression may be a peripheral physiological function of B-endorphin which is mediated by mechanisms distinct from traditional opiate receptors.