Form and Function in Cell Motility: From Fibroblasts to Keratocytes
Form and Function in Cell Motility: From Fibroblasts to Keratocytes
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DOI：
10.1016/j.bpj.2009.12.4303
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发表时间：
2010-04-21
影响因子：
3.4
通讯作者：
Dembo, Micah
中科院分区：
文献类型：
--
作者：
Herant, Marc;Dembo, Micah
很明显，马是用来奔跑的，但关于运动细胞的类似说法就不那么明显了。在这里，通过应用一种新的计算技术来探索细胞运动性中结构-功能关系的基础，该技术允许对细胞在平板上迁移的真实三维模拟。通过这种方法，一些网络细胞自发地显示出爬行成纤维细胞的典型不规则突起周期和手镜形态，而另一些则显示出鱼角质细胞稳定的滑动运动和新月状形态。角质细胞的模体是由于细胞骨架从后到前的最佳循环，从而使更多的外围可以用于突出。这些计算是朝着弥合整个细胞的综合力学和生物物理学与细胞骨架组件的微观分子生物学之间的差距迈出的一步。
It is plain enough that a horse is made for running, but similar statements about motile cells are not so obvious. Here the basis for structure-function relations in cell motility is explored by application of a new computational technique that allows realistic three-dimensional simulations of cells migrating on flat substrata. With this approach, some cyber cells spontaneously display the classic irregular protrusion cycles and handmirror morphology of a crawling fibroblast, and others the steady gliding motility and crescent morphology of a fish keratocyte. The keratocyte motif is caused by optimal recycling of the cytoskeleton from the back to the front so that more of the periphery can be devoted to protrusion. These calculations are a step toward bridging the gap between the integrated mechanics and biophysics of whole cells and the microscopic molecular biology of cytoskeletal components.