Pathogen Free Conditions Slow the Onset of Neurodegeneration in a Mouse Model of Nerve Growth Factor Deprivation
Pathogen Free Conditions Slow the Onset of Neurodegeneration in a Mouse Model of Nerve Growth Factor Deprivation
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DOI：
10.3233/jad-2012-120427
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发表时间：
2012-01-01
影响因子：
4
通讯作者：
Cattaneo, Antonino
中科院分区：
文献类型：
--
作者：
Capsoni, Simona;Carucci, Nicola Maria;Cattaneo, Antonino
几项研究表明，在衰老和慢性神经退行性疾病期间发生的全身性感染可引起过度的免疫反应，导致神经退行性疾病和认知能力下降的进展。然而，在阿尔茨海默病动物模型中，直接解决微生物环境与神经变性发作之间关系的研究还很缺乏。在这里，我们表明，神经退行性变的发病，转基因小鼠发展时，提出了在传统的畜牧业减缓时，提高抗神经生长因子转基因小鼠在鼠病原体自由的条件。
Several studies suggest that systemic infection occurring during aging and chronic neurodegenerative diseases can evoke an exaggerated immune response that contributes to the progression of neurodegeneration and cognitive decline. However, studies directly addressing the relationship between microbial environment and the onset of neurodegeneration in Alzheimer's disease animal models are lacking. Here we show that the onset of neurodegeneration that transgenic mice develop when raised in conventional husbandry slows down when raising anti-nerve growth factor transgenic mice in a murine pathogen free condition.