25-Hydroxyvitamin D serum levels and melanoma risk: a case-control study and evidence synthesis of clinical epidemiological studies
25-Hydroxyvitamin D serum levels and melanoma risk: a case-control study and evidence synthesis of clinical epidemiological studies
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DOI：
10.1097/cej.0000000000000437
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发表时间：
2019-05-01
影响因子：
2.4
通讯作者：
Carlesimo, Marta
中科院分区：
文献类型：
--
作者：
Cattaruzza, Maria Sofia;Pisani, Daniela;Carlesimo, Marta
越来越多的证据表明，维生素D途径可能在黑色素瘤中发挥作用。本研究的目的是调查25-羟基维生素D [25(OH)D]血清水平与皮肤黑色素瘤风险之间的关系。对137例黑色素瘤病例（诊断时收集的血清样本）和99例健康对照（10月至4月期间收集的血清样本）进行了病例对照研究，并在有关该专题的临床流行病学研究的证据综合框架内进行了评估，以促进比较和总结迄今为止产生的科学证据。黑色素瘤患者与健康对照者血清维生素D中位数水平差异有统计学意义(18.0 vs. 27.8 ng/ml， P
There is accumulating evidence that the vitamin D pathway may play a role in melanoma. The aim of this study was to investigate the association between 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of cutaneous melanoma. A case-control study with 137 incident cases of melanoma (serum samples collected at the time of diagnosis) and 99 healthy controls (serum samples collected between October and April) was carried out and evaluated in the framework of an evidence synthesis of clinical epidemiological studies on the topic to facilitate comparisons and summarize the scientific evidence produced so far. There was a statistically significant difference in the median levels of serum vitamin D between melanoma patients and healthy controls (18.0 vs. 27.8 ng/ml, P