Blood-borne and sexual transmission of human herpesvirus 8 in women with or at risk for human immunodeficiency virus infection.
Blood-borne and sexual transmission of human herpesvirus 8 in women with or at risk for human immunodeficiency virus infection.
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DOI：
10.1056/nejm200103013440904
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发表时间：
2001-03-01
影响因子：
158.5
通讯作者：
Pellett, PE
中科院分区：
文献类型：
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作者：
Cannon, MJ;Dollard, SC;Pellett, PE
背景：人类疱疹病毒 8 (HHV-8) 是卡波西肉瘤的病原体，在男性同性恋者中通过性传播，但对其在女性中的传播知之甚少。尽管已在血液中检测到 HHV-8，但尚无明确的血源性传播证据。 方法：我们对巴尔的摩、纽约州底特律和罗德岛州普罗维登斯的 1295 名报告有高危性行为或吸毒行为的女性确定了 HHV-8 感染的危险因素。采用两种酶联免疫吸附测定进行 HHV-8 血清学研究。 结果：在单变量分析中，HHV-8 与黑人种族、西班牙裔背景、教育水平较低以及梅毒、人类免疫缺陷病毒 (HIV)、乙型肝炎病毒 (HBV) 或丙型肝炎病毒 (HCV) 感染相关。 HHV-8 血清阳性的风险随着注射药物使用频率的增加而增加 (P
Background: Human herpesvirus 8 (HHV-8), the causal agent of Kaposi's sarcoma, is transmitted sexually among homosexual men, but little is known of its transmission among women. Although HHV-8 has been detected in blood, there has been no clear evidence of blood-borne transmission.Methods: We identified risk factors for HHV-8 infection in 1295 women in Baltimore, Detroit, New York, and Providence, Rhode Island, who reported high-risk sexual behavior or drug use. HHV-8 serologic studies were performed with two enzyme-linked immunosorbent assays.Results: In univariate analyses, HHV-8 was associated with black race, Hispanic ethnic background, a lower level of education, and infection with syphilis, the human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV). The risk of seropositivity for HHV-8 increased with the frequency of injection-drug use (P