Mitophagy: Link to cancer development and therapy
Mitophagy: Link to cancer development and therapy
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DOI：
10.1016/j.bbrc.2016.10.088
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发表时间：
2017-01-15
影响因子：
3.1
通讯作者：
Zhivotovsky, Boris
中科院分区：
文献类型：
--
作者：
Kulikov, Andrey V.;Luchkina, Ekaterina A.;Zhivotovsky, Boris
线粒体自噬是线粒体通过自噬途径进行的选择性降解，是细胞线粒体质量控制的重要机制。线粒体自噬负责去除功能失调或受损的线粒体，这对正常的细胞生理和组织发育至关重要。在许多情况下，参与线粒体自噬、肿瘤发生和细胞死亡调控的途径是重叠的，可能是由共同的上游信号触发的，这些信号汇聚在线粒体。在对致瘤压力的反应中，线粒体转换调节不当可能刺激或抑制肿瘤的发生。因此，分析有丝自噬、细胞死亡和肿瘤发生过程之间的串扰，对于确定刺激细胞死亡和选择性消除癌细胞的靶标具有重要意义。在这篇综述中，我们分析了线粒体自噬调节的机制，受损线粒体利用的途径，以及干预线粒体自噬如何影响肿瘤细胞对治疗的抵抗。(C) 2016 Elsevier Inc.版权所有。
Mitophagy, the selective degradation of mitochondria via the autophagic pathway, is a vital mechanism of mitochondrial quality control in cells. Mitophagy is responsible for the removal of malfunctioning or damaged mitochondria, which is essential for normal cellular physiology and tissue development. Pathways involved in the regulation of mitophagy, tumorigenesis, and cell death are overlapping in many cases and may be triggered by common upstream signals, which converge at the mitochondria. The failure to properly modulate mitochondrial turnover in response to oncogenic stresses can either stimulate or suppress tumorigenesis. Thus, the analysis of crosstalk among the processes of mitophagy, cell death and tumorigenesis is important for the identification of targets responsible for the stimulation of cell death and selective elimination of cancer cells. In the present review, we analyze the mechanisms of mitophagy regulation, the pathways underlying the utilization of damaged mitochondria, and how intervention with mitophagy can affect tumor cell resistance to treatment. (C) 2016 Elsevier Inc. All rights reserved.