A telemedicine instrument for remote evaluation of tremor: design and initial applications in fatigue and patients with Parkinson's Disease
A telemedicine instrument for remote evaluation of tremor: design and initial applications in fatigue and patients with Parkinson's Disease
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DOI：
10.1186/1475-925x-10-14
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发表时间：
2011-02-09
影响因子：
3.9
通讯作者：
Melo, Pedro L.
中科院分区：
文献类型：
--
作者：
Barroso Junior, Mario C.;Esteves, Guilherme P.;Melo, Pedro L.
简介：本文提出了一种新颖的系统，结合了紧凑的移动的仪器和互联网通信的震颤远程评估。该系统在帕金森病中具有很高的应用潜力，并通过TCP/IP协议连接到Internet。通过加速度传感器对震颤信号进行传感，并利用虚拟仪器进行数据处理、显示和存储。该系统提供的峰值频率（FP），振幅（AFP）和功率在这个频率（PFP），总功率（Ptot），和功率在低（1-4 Hz）和高（4-7 Hz）频率（Plf和Phf，分别）。方法：所提出的系统检测异常震颤的能力最初证明了在正常受试者的疲劳研究。与生理学基本原理密切一致的是，疲劳的存在增加了fp、Afp、Pfp和Pt（p < 0.05），而疲劳的消除降低了所有提到的参数（p < 0.05）。该系统还在帕金森病患者的初步体内测试中进行了评估。AFP、Pfp、Ptot、Plf和Phf是检测该病不良反应的最准确参数（Se = 100%，Sp = 100%），其次是fp（Se = 100%，Sp = 80%）。互联网传输，逼真地模拟临床条件的测试显示足够的采集和分析的震颤信号，也表明，用户可以充分接收医疗recommendations.Conclusions：所提出的系统可以用于广泛的远程医疗方案，使家庭评估震颤发生在特定的医疗和有助于降低成本的援助提供给这些患者。
Introduction: A novel system that combines a compact mobile instrument and Internet communications is presented in this paper for remote evaluation of tremors. The system presents a high potential application in Parkinson's disease and connects to the Internet through a TCP/IP protocol. Tremor transduction is carried out by accelerometers, and the data processing, presentation and storage were obtained by a virtual instrument. The system supplies the peak frequency (fp), the amplitude (Afp) and power in this frequency (Pfp), the total power (Ptot), and the power in low (1-4 Hz) and high (4-7 Hz) frequencies (Plf and Phf, respectively).Methods: The ability of the proposed system to detect abnormal tremors was initially demonstrated by a fatigue study in normal subjects. In close agreement with physiological fundamentals, the presence of fatigue increased fp, Afp, Pfp and Pt (p < 0.05), while the removal of fatigue reduced all the mentioned parameters (p < 0.05). The system was also evaluated in a preliminary in vivo test in parkinsonian patients. Afp, Pfp, Ptot, Plf and Phf were the most accurate parameters in the detection of the adverse effects of this disease (Se = 100%, Sp = 100%), followed by fp (Se = 100%, Sp = 80%). Tests for Internet transmission that realistically simulated clinical conditions revealed adequate acquisition and analysis of tremor signals and also revealed that the user could adequately receive medical recommendations.Conclusions: The proposed system can be used in a wide spectrum of telemedicine scenarios, enabling the home evaluation of tremor occurrence under specific medical treatments and contributing to reduce the costs of the assistance offered to these patients.