Depression, facilitation, and mobilization of transmitter at the rat diaphragm neuromuscular junction.
Depression, facilitation, and mobilization of transmitter at the rat diaphragm neuromuscular junction.
复制标题
大鼠膈肌神经肌肉接头处递质的抑制、促进和动员。
DOI：
10.1152/ajpcell.1979.237.1.c31
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
D. Wilson
中科院分区：
文献类型：
--
作者：
D. Wilson
The characteristics of depression, facilitation, and mobilization of transmitter were examined at the rat diaphragm neuromuscular junction. Intracellular recording techniques were used to monitor end-plate potentials (EPPs), miniature end-plate potentials (MEPPs) and the muscle resting potentials. The cut-muscle technique was used to prevent muscle action potentials. Quantal release was determined by the direct method. The binomial statistical parameters, releasable store (n) and probability of release (p), were examined under various stimulating conditions to determine the basis for depression and facilitation. The present experiments demonstrate that p remains unchanged during repetitive nerve stimulation at low or moderately high frequencies. The experiments demonstrate that depression is due to a decrease in n and facilitation is due to an elevation in n. It is suggested that the increase in n during facilitation is due to a transient recruitment of inactive releasing sites. Substantial replenishment of n by mobilization occurs within a few ms after a stimulus but a slow residual rate of mobilization is needed to replenish n to resting levels.
