Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?
Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?
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触发 - 母亲的 COVID-19 是否会对新生儿产生过度的免疫反应？
DOI：
10.1038/s41390-023-03007-0
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发表时间：
2024
影响因子：
3.6
通讯作者：
Sampath,Venkatesh
中科院分区：
文献类型：
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作者：
Bradley,Todd;Tucker,Megan;Sampath,Venkatesh
妊娠期冠状病毒病 2019 (COVID-19) 暴露对新生儿免疫力的影响尚不完全清楚。虽然垂直传播给胎儿的情况很少见，但母体接触 COVID-19 可能会通过诱发胎盘病理或通过新生儿免疫程序间接对新生儿产生不利影响。为了研究后者，吉利等人。分析了从暴露于绒毛膜羊膜炎、妊娠期 COVID-19 的新生儿和未暴露的对照中获得的脐带血单核细胞 (CBMC) 中的细胞因子水平。他们观察到，胎儿暴露于由 SARS-CoV-2 感染或绒毛膜羊膜炎引起的母体炎症中，会夸大培养的 CBMC 中对新生儿细菌病原体的促炎细胞因子反应。虽然绒毛膜羊膜炎和 COVID-19 暴露都会夸大细胞因子的表达，但免疫细胞群和细胞类型特异性反应存在差异。这些有趣的发现表明，即使胎儿没有感染，胎儿暴露于炎症刺激也会导致新生儿免疫细胞表型和功能发生变化，从而导致免疫激活增强。这项研究的结果与儿科 COVID-19 中观察到的促炎症反应减弱的趋势不同，后者导致疾病严重程度降低。未来的研究需要探索新生儿免疫程序的潜在机制、与免疫程序相关的母体暴露的时间和严重程度以及长期健康后果。
The consequences of gestational coronavirus disease 2019(COVID-19) exposure on neonatal immunity are incompletely understood. While vertical transmission to the fetus is rare, maternal COVID-19 exposure can adversely impact the neonate by inducing placental pathology, or indirectly, via neonatal immune programming. To investigate the latter, Gilley et al. analyzed cytokine levels in cord blood mononuclear cells (CBMCs) obtained from neonates exposed to chorioamnionitis, gestational COVID-19, and unexposed controls. They observed that fetal exposure to maternal inflammation, by either SARS-CoV-2 infection or chorioamnionitis, exaggerated the pro-inflammatory cytokine response to neonatal bacterial pathogens in cultured CBMCs. While both chorioamnionitis and COVID-19 exposure exaggerated cytokine expression, there were differences in immune cell populations and cell-type specific responses. These interesting findings indicate that fetal exposure to inflammatory stimuli, even without fetal infection, results in changes in the neonatal immune cell phenotype and function leading to heightened immune activation. The results of this study differ from a trend towards a muted pro-inflammatory response seen in pediatric COVID-19, which is attributed to cause decreased disease severity. The mechanisms underlying neonatal immune programming, the timing and severity of maternal exposure in relationship to immune programming and long-term health consequences need to be explored in future studies.