Micro-RNAs and High-Density Lipoprotein Metabolism.
Micro-RNAs and High-Density Lipoprotein Metabolism.
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DOI：
10.1161/atvbaha.116.307028
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Fernández-Hernando C
中科院分区：
文献类型：
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作者：
Canfrán-Duque A;Lin CS;Goedeke L;Suárez Y;Fernández-Hernando C
改善心血管疾病（CVD）的预防和治疗是西方社会的挑战之一，缺血性心脏病和中风是导致死亡的主要原因。早期的流行病学研究表明，循环高密度脂蛋白胆固醇（HDL-C）和心血管疾病（CVD）之间呈负相关。HDL的心脏保护作用是由于其能够通过称为胆固醇逆向转运（RCT）的过程将胆固醇从动脉壁中的斑块中清除到肝脏中进行排泄。大量研究报道了microRNA（miRNAs）在RCT中不同步骤的调控中发挥的作用，包括HDL生物合成、胆固醇流出、肝脏胆固醇摄取和胆汁酸合成与分泌。由于它们能够控制HDL代谢和功能的不同方面，miRNA已成为对抗CVD的潜在治疗靶点。本文就miRNA调控HDL代谢的研究进展作一综述。我们还讨论了HDL颗粒如何作为miRNA的载体以及含HDL的miRNA作为CVD生物标志物的潜在用途。
Improved prevention and treatment of cardiovascular diseases (CVD) is one of the challenges in Western societies, where ischemic heart disease and stroke are the leading cause of death. Early epidemiological studies have shown an inverse correlation between circulating high-density lipoprotein cholesterol (HDL-C) and cardiovascular disease (CVD). The cardioprotective effect of HDL is due to its ability to remove cholesterol from plaques in the artery wall to the liver for excretion by a process known as reverse cholesterol transport (RCT). Numerous studies have reported the role that microRNAs (miRNAs) play in the regulation of the different steps in RCT, including HDL biogenesis, cholesterol efflux, cholesterol uptake in the liver and bile acid synthesis and secretion. Due to their ability to control different aspects of HDL metabolism and function, miRNAs have emerged as potential therapeutic targets to combat CVDs. In this review, we summarize the recent advances in the miRNA-mediated control of HDL metabolism. We also discuss how HDL particles serve as carriers of miRNAs and the potential use of HDL-containing miRNAs as CVD biomarkers.