Unraveling Divergent Gene Expression Profiles in Bicuspid and Tricuspid Aortic Valve Patients with Thoracic Aortic Dilatation: The ASAP Study
Unraveling Divergent Gene Expression Profiles in Bicuspid and Tricuspid Aortic Valve Patients with Thoracic Aortic Dilatation: The ASAP Study
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DOI：
10.2119/molmed.2011.00286
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发表时间：
2011-11-01
影响因子：
5.7
通讯作者：
Eriksson, Per
中科院分区：
文献类型：
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作者：
Folkersen, Lasse;Wagsater, Dick;Eriksson, Per
胸主动脉瘤（TAA）是二叶式主动脉瓣（BAV）患者的常见并发症，是最常见的先天性心脏病。由于未知原因，TAA发生在更年轻的年龄，BAV患者的发生率高于三尖瓣主动脉瓣（TAV）患者，导致主动脉夹层和破裂的风险增加。为了研究BAV患者中TAA发生率的增加，我们从131例BAV和TAV患者的非扩张和扩张动脉瘤中获得了组织活检样本。从对照组和患者的主动脉内膜-中膜和外膜（总共345个样品）分析全局基因表达谱。在被发现的与扩张有差异表达的基因中，只有少数（
Thoracic aortic aneurysm (TAA) is a common complication in patients with a bicuspid aortic valve (BAV), the most frequent congenital heart disorder. For unknown reasons TAA occurs at a younger age, with a higher frequency in BAV patients than in patients with a tricuspid aortic valve (TAV), resulting in an increased risk for aortic dissection and rupture. To investigate the increased TAA incidence in BAV patients, we obtained tissue biopsy samples from nondilated and dilated aortas of 131 BAV and TAV patients. Global gene expression profiles were analyzed from controls and from aortic intima-media and adventitia of patients (in total 345 samples). Of the genes found to be differentially expressed with dilation, only a few (