Ictal magnetic source imaging as a localizing tool in partial epilepsy
Ictal magnetic source imaging as a localizing tool in partial epilepsy
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DOI：
10.1212/01.wnl.0000032493.83875.0b
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发表时间：
2002-11-26
期刊：
影响因子：
9.9
通讯作者：
Engel, J
中科院分区：
文献类型：
--
作者：
Eliashiv, DS;Elsas, SM;Engel, J
目的：探讨发作期脑磁图（MEG）记录在癫痫患者术前评估中的可行性和实用性。研究方法：20例频繁或可预测的癫痫发作患者进行了研究，目的是使用大阵列单探头37通道或双探头74通道生物磁测量仪捕获癫痫发作。结果：20例新皮质癫痫患者中6例发作期脑磁图记录成功。在另一名患者中，捕获了癫痫发作，但运动伪影使MEG记录不可能。根据侵入性EEG记录和术后结果，6例患者中有3例发作期MEG提供的定位信息上级发作间期MEG。在6名患者中，5名患者的MEG定位发作至少相当于侵入性EEG，2名患者的术后结果确定为上级。结论：有必要进行更大规模的研究，以确认频繁或容易诱发的新皮层癫痫发作患者的发作期MEG记录可以提供与侵入性EEG记录相当或上级的定位信息。
Objective: To determine the feasibility and usefulness of ictal magnetoencephalography (MEG) recordings in the presurgical evaluation of patients with epilepsy. Methods: Twenty patients with frequent or predictable seizures were studied with the intent to capture seizures using a large array single-probe 37-channel or dual-probe 74-channel biomagnetometer. Results: Successful ictal MEG recordings were made in 6 of 20 patients with neocortical epilepsy. In one other patient, a seizure was captured but movement artifact made MEG recordings impossible. As determined by invasive EEG recording and postsurgical outcome, ictal MEG provided localizing information that was superior to interictal MEG in three of the six patients. Localization of ictal onset by MEG was at least equivalent to invasive EEG in five of the six patients, and was superior in two patients as determined by postsurgical outcome. Conclusion: Larger studies are necessary to confirm that ictal MEG recordings in patients with frequent or easily provoked neocortical seizures can contribute localizing information equivalent or superior to invasive EEG recording.