Ribozymes
Ribozymes
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DOI：
10.1016/j.sbi.2007.05.003
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发表时间：
2007-06-01
影响因子：
6.8
通讯作者：
Scott, William G.
中科院分区：
文献类型：
--
作者：
Scott, William G.
在过去的两年里，核酶的结构分子生物学又向前迈进了一大步。在20世纪80年代初发现核酶之前，所有的酶都被认为是蛋白质。直到1994年才有关于核酶的详细结构信息。现在，在过去的两年里，几乎所有已知的核酶都有了近原子分辨率的晶体结构。最新增加的包括核糖核酸酶P，I组内含子结构，核糖体（肽基转移酶似乎是一种核酶）和几种较小的核酶，包括Diels-Alderase，glmS核酶和一种新的锤头状核酶结构，调和了12年的不和谐。虽然不是所有的核酶都是金属酶，但酸碱催化似乎是所有核酶以及它们的许多蛋白质表亲所共有的普遍性质。
The structural molecular biology of ribozymes took another great leap forward during the past two years. Before ribozymes were discovered in the early 1980s, all enzymes were thought to be proteins. No detailed structural information on ribozymes became available until 1994. Now, within the past two years, near atomic resolution crystal structures are available for almost all of the known ribozymes. The latest additions include ribonuclease P, group I intron structures, the ribosome (the peptidyl transferase appears to be a ribozyme) and several smaller ribozymes, including a Diels-Alderase, the glmS ribozyme and a new hammerhead ribozyme structure that reconciles 12 years of discord. Although not all ribozymes are metalloenzymes, acid-base catalysis appears to be a universal property shared by all ribozymes as well as many of their protein cousins.