Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.
Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome.
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DOI：
10.1155/2015/496169
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发表时间：
2015
影响因子：
5.3
通讯作者：
Reza HM
中科院分区：
文献类型：
--
作者：
Alam MA;Uddin R;Subhan N;Rahman MM;Jain P;Reza HM
近年来，糖尿病、肥胖和代谢综合征在发达国家和发展中国家都变得流行。补充和替代药物自古以来就被用于治疗糖尿病和心血管疾病。苦瓜在孟加拉国和亚洲其他几个国家被广泛用作日常食品中的蔬菜。苦瓜果实提取物具有较强的抗氧化和降血糖活性。最近对这种植物提取物的科学评估也在实验动物和临床研究中显示出对糖尿病和肥胖相关代谢功能障碍的潜在治疗益处。这些有益作用可能是通过诱导脂质和脂肪代谢基因的表达以及增加AMPK和PPARs的功能等来介导的。本文就苦瓜提取物对代谢综合征的治疗作用及其可能的作用机制作一综述。
Diabetes, obesity, and metabolic syndrome are becoming epidemic both in developed and developing countries in recent years. Complementary and alternative medicines have been used since ancient era for the treatment of diabetes and cardiovascular diseases. Bitter melon is widely used as vegetables in daily food in Bangladesh and several other countries in Asia. The fruits extract of bitter melon showed strong antioxidant and hypoglycemic activities in experimental condition both in vivo and in vitro. Recent scientific evaluation of this plant extracts also showed potential therapeutic benefit in diabetes and obesity related metabolic dysfunction in experimental animals and clinical studies. These beneficial effects are mediated probably by inducing lipid and fat metabolizing gene expression and increasing the function of AMPK and PPARs, and so forth. This review will thus focus on the recent findings on beneficial effect of Momordica charantia extracts on metabolic syndrome and discuss its potential mechanism of actions.