Two-Way Calf to Dam Major Histocompatibility Class I Compatibility Increases Risk for Retained Placenta in Cattle
Two-Way Calf to Dam Major Histocompatibility Class I Compatibility Increases Risk for Retained Placenta in Cattle
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DOI：
10.1111/j.1600-0897.2011.01085.x
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发表时间：
2012-03-01
影响因子：
3.6
通讯作者：
Koets, Ad P.
中科院分区：
文献类型：
--
作者：
Benedictus, Lindert;Thomas, Aaron J.;Koets, Ad P.
问题 在牛中，胎盘滞留 (RP) 被认为是由母体免疫系统对胎膜的免疫介导排斥失败引起的，并且与小牛和母牛之间的主要组织相容性 (MHC) I 类相容性相关。 研究方法 为了研究 RP 与小牛-母牛-孙辈组合之间的不同 MHC I 类相容性之间的关联，进行了大规模并行焦磷酸测序。 用于确定具有和不具有 RP 的奶牛的 MHC I 类单倍型。结果 小牛与母牛 MHC I 类相容性的双向性导致 RP 的高风险。小牛 RP 的风险有较高的风险，与母体 MHC I 类相容性不符。 结论 我们的结论是，在双向相容妊娠中，母体免疫系统无法排斥胎膜，胎儿免疫系统不会针对母体 MHC I 类抗原产生免疫反应，从而影响母体免疫系统对胎膜的免疫介导排斥。母体免疫系统缺乏免疫介导的胎膜排斥会增加发生 RP 的风险。
Problem In cattle, retained placenta (RP) is suggested to arise from failure of immune-mediated rejection of the fetal membranes by the maternal immune system and is associated with major histocompatibility (MHC) class I compatibility between calf and dam.Method of study To study the association between RP and different MHC class I compatibilities between calf-dam-granddam combinations, massively parallel pyrosequencing was used to determine the MHC class I haplotypes of cows with and without RP.Results Two-way calf to dam MHC class I compatibility gave a high risk for RP. There was a tendency for a higher risk for RP with calf to dam MHC class I compatibility.Conclusions We concluded that in two-way compatible pregnancies, the maternal immune system fails to reject the fetal membranes, and the fetal immune system does not mount an immune response against maternal MHC class I antigens that could influence the immune-mediated rejection of the fetal membranes by the maternal immune system. The lack of immune-mediated rejection of the fetal membranes by the maternal immune system increases the risk of occurrence of RP.