Prognostic Value of Histopathological Features and Loss of H3K27me3 Immunolabeling in Anaplastic Meningioma: A Multicenter Retrospective Study
Prognostic Value of Histopathological Features and Loss of H3K27me3 Immunolabeling in Anaplastic Meningioma: A Multicenter Retrospective Study
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DOI：
10.1093/jnen/nlaa038
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发表时间：
2020-07-01
影响因子：
3.2
通讯作者：
Bielle, Franck
中科院分区：
文献类型：
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作者：
Gauchotte, Guillaume;Peyre, Matthieu;Bielle, Franck
间变性脑膜瘤（AM）（WHO III级）的诊断是基于高有丝分裂指数（MI）和/或明显的间变性。关于显性间变性的可重复性和预后价值的数据很少。此外，H3 K27 me 3丢失在AM中的预后价值尚未得到证实。我们的目的是在一个多中心的系列66 AM中评估WHO标准和H3 K27 me 3丢失的可重复性和预后价值。观察者间的重现性对于确定WHO分级（Kappa = 0.671）和MI（组内相关系数[ICC] = 0.649）是良好的，并且对于评估明显的间变性（Kappa = 0.366）是公平的。显示高MI的脑膜瘤患者的总生存期（OS）显著短于显示明显间变性但无高MI的脑膜瘤患者（p=0.009）。在伴有低MI的明显间变性的情况下，OS显著降低（
The diagnosis of anaplastic meningioma (AM) (WHO grade III) is based on the presence of a high mitotic index (MI) and/or overt anaplasia. Only few data exist about the reproducibility and prognostic value of overt anaplasia. Additionally, the prognostic value of H3K27me3 loss in AM has not yet been demonstrated. Our objectives were to evaluate the reproducibility and prognostic value of WHO criteria and H3K27me3 loss in a multicenter series of 66 AM. Interobserver reproducibility was good for the determination of WHO grade (Kappa = 0.671) and MI (intraclass correlation coefficient [ICC] = 0.649), and fair for assessment of overt anaplasia (Kappa = 0.366). Patients with meningiomas showing high MI had significantly shorter overall survival (OS) than patients with meningiomas showing overt anaplasia without high MI (p=0.009). OS was significantly lower in case of overt anaplasia with low MI (