Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.
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DOI：
10.1016/j.biocel.2008.06.010
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发表时间：
2009-01
影响因子：
4
通讯作者：
Harikumar, Kuzhuvelil B.
中科院分区：
文献类型：
--
作者：
Aggarwal, Bharat B.;Harikumar, Kuzhuvelil B.
虽然在大多数情况下是安全的，但古老的治疗方法被忽视了，因为它们的活性成分和分子靶点都没有很好的定义。然而，姜黄素的情况并非如此，姜黄素是一种黄色色素物质和姜黄（姜黄）的成分，它在世纪前就被发现了。几个世纪以来，人们已经知道姜黄具有抗炎活性，但在过去二十年中进行的广泛研究表明，姜黄的这种活性是由于姜黄素，一种二阿魏酰甲烷。该试剂已被证明可调节许多转录因子、细胞因子、蛋白激酶、粘附分子、氧化还原状态和与炎症相关的酶。炎症过程已被证明在大多数慢性疾病中起主要作用，包括神经退行性疾病、心血管疾病、肺部疾病、代谢疾病、自身免疫疾病和肿瘤疾病。在目前的综述中，我们提供了姜黄素在预防和治疗各种促炎性慢性疾病中的潜在作用的证据。这些特征，结合药理学安全性和可忽略的成本，使姜黄素成为一种有吸引力的药物，以进一步探索。
Although safe in most cases, ancient treatments are ignored because neither their active component nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (Curcuma longa), which was identified more than a century ago. For centuries it has been known that turmeric exhibits anti-inflammatory activity, but extensive research performed within the past two decades has shown that the this activity of turmeric is due to curcumin, a diferuloylmethane. This agent has been shown to regulate numerous transcription factors, cytokines, protein kinases, adhesion molecules, redox status and enzymes that have been linked to inflammation. The process of inflammation has been shown to play a major role in most chronic illnesses, including neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. In the current review, we provide evidence for the potential role of curcumin in the prevention and treatment of various pro-inflammatory chronic diseases. These features, combined with the pharmacological safety and negligible cost, render curcumin an attractive agent to explore further.
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影响因子：
3.6
作者：
Aoki, Hiroshi;Takada, Yasunari;Kondo, Yasuko
通讯作者：
Kondo, Yasuko
影响因子：
4
作者：
Aggarwal, Bharat B.;Sethi, Gautam;Shishodia, Shishir
通讯作者：
Shishodia, Shishir
DOI：
10.1073/pnas.0600134103
发表时间：
2006-02-28
影响因子：
11.1
作者：
Atamna, H;Boyle, K
通讯作者：
Boyle, K
影响因子：
4.8
作者：
Balasubramanyam, K;Varier, RA;Kundu, TK
通讯作者：
Kundu, TK
影响因子：
4.4
作者：
Al-Omar, Fadhel A.;Nagi, Mahmoud N.;Al-Majed, Abdulhakeem A.
通讯作者：
Al-Majed, Abdulhakeem A.