Immune-challenged house wren broods differ in the relative strengths of their responses among different axes of the immune system
Immune-challenged house wren broods differ in the relative strengths of their responses among different axes of the immune system
复制标题
DOI：
10.1111/j.1420-9101.2008.01503.x
复制
发表时间：
2008-05-01
影响因子：
2.1
通讯作者：
Thompson, C. F.
中科院分区：
文献类型：
--
作者：
Forsman, A. M.;Vogel, L. A.;Thompson, C. F.
免疫系统的单一成分被广泛用于评估自由生活的脊椎动物的免疫功能。然而，由于不同的免疫成分是由不同类型的威胁触发的，可能会受到独立的监管，因此没有理由认为它们在受到挑战时应该做出类似的反应。我们研究了雏鸟的三种常见的免疫反应，皮肤免疫活性(植物血凝素试验)、抗体反应(破伤风类毒素免疫)和血浆杀菌活性(大肠杆菌杀灭)是否呈正相关。多变量分析表明，雏鸟(即巢)的总体免疫反应性存在显著差异，这主要归因于血浆杀菌活性的差异。雏鸟体液免疫反应与皮肤免疫活性呈负相关，与血浆杀菌活性呈正相关。我们发现，在雏鸟个体间的这些免疫指标之间没有显著的关系。我们的结果表明，不同的雏鸟(即家庭)对免疫系统的不同分支进行了不同的投资。需要进一步的研究来确定母体、遗传和环境影响对这种生理偏见表达的作用。
Single components of the immune system are widely used to assess immune function in free-living vertebrates. However, as different immunological components are triggered by different types of threats and may be regulated independently, there is little reason to assume that they should respond similarly if challenged. We investigated whether three commonly assayed immune responses, cutaneous immune activity (phytohaemagglutinin assay), antibody response (tetanus toxoid immunization), and plasma bactericidal activity (Escherichia coli killing) are positively related in nestling house wrens (Troglodytes aedon). Multivariate analysis revealed significant differences in overall immune responsiveness among broods (i.e. nests), primarily attributable to differences in plasma bactericidal activity. Among broods, humoral immune response was negatively related to cutaneous immune activity and positively related to plasma bactericidal activity. We found no significant relationships among these measures of immunity among individual nestlings within broods. Our results suggest that different broods (i.e. families) invest differentially in the various branches of the immune system. Further study is needed to characterize the roles of maternal, genetic and environmental effects on the expression of this physiological bias.