Dual-functional lanthanide metal organic frameworks for visual and ultrasensitive ratiometric fluorescent detection of phosphate based on aggregation-induced energy transfer
Dual-functional lanthanide metal organic frameworks for visual and ultrasensitive ratiometric fluorescent detection of phosphate based on aggregation-induced energy transfer
复制标题
双功能镧系金属有机框架，用于基于聚集诱导能量转移的磷酸盐的视觉和超灵敏比率荧光检测
DOI：
10.1016/j.aca.2020.07.066
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发表时间：
2020-10-09
影响因子：
6.2
通讯作者：
Tong, Changlun
中科院分区：
文献类型：
--
作者：
Li, Gaiyan;Tong, Changlun
磷酸盐（Pi）不仅在生理过程中起着重要作用，而且是水生生态系统的重要指标。合成了双功能镧系金属有机框架（mof），用于基于聚集诱导能量转移的视觉和超灵敏比例荧光检测Pi。在mof材料中，环丙沙星（CIP）作为能量供体导致Eu3+的荧光增强；邻苯二甲酸的引入使CIP-Eu3+络合物聚集，Eu3+在614 nm处的红色特征荧光进一步增强（约40倍）。将Pi加入到mof溶液中，CIP从mof中释放出来，Eu3+的红色荧光被猝灭，CIP的蓝色荧光同时恢复，从而制备了用于Pi检测的比例荧光探针。基于CIP-Eu3+配合物分子间能量转移的荧光响应对Pi非常敏感。该探针的检出限（3 sigma/K）为超灵敏，可达4.4 nM。所研究的17种常见金属离子和14种阴离子等可能的干扰物质对π的检测没有干扰。比率荧光探针已成功地应用于人体尿液和湖水样品中π的测定。本研究为比例荧光探针的制备提供了新的思路，并在生物和环境样品中具有广阔的应用前景。(C) 2020 Elsevier B.V.版权所有
Phosphate (Pi) not only plays a significant role in physiological processes, but also is an important indicator for aquatic ecosystems. The dual-functional lanthanide metal organic frameworks (MOFs) were synthesized for visual and ultrasensitive ratiometric fluorescent detection of Pi based on aggregation-induced energy transfer. In the MOFs material, ciprofloxacin (CIP) functions as an energy donor and results in the fluorescence enhancement of Eu3+; the introduction of pyromellitic acid can cause the aggregation of the CIP-Eu3+ complex, and red characteristic fluorescence of Eu3+ at 614 nm is further enhanced (about 40 times). When Pi is added to the MOFs solution, CIP is released from the MOFs, red fluorescence of Eu3+ is quenched and blue fluorescence of CIP is simultaneously recovered, thereby a ratiometric fluorescent probe for the detection of Pi was fabricated. The fluorescent response based on intermolecular energy transfer of the CIP-Eu3+ complex is very sensitive to Pi. The limit of detection (3 sigma/K) of the probe is ultrasensitive and attains 4.4 nM. The possible interferential substances such as 17 common metal ions and 14 anions investigated do not interfere with the Pi detection. The ratiometric fluorescent probe has been successfully used in the determination of Pi in real human urine and lake water samples. This work may supply a new strategy for fabricating ratiometric fluorescent probe and a prospective application in biological and environmental samples. (C) 2020 Elsevier B.V. All rights reserved.