The beige mutation in the mouse selectively impairs natural killer cell function
The beige mutation in the mouse selectively impairs natural killer cell function
复制标题
小鼠的米色突变选择性损害自然杀伤细胞功能
作者：
J. Roder;A. Duwe
影响特定细胞群的生殖系突变通常是阐明这些细胞在复杂生物系统（如肿瘤排斥）中功能的有价值工具。我们在这里报告，在小鼠中的突变基因称为米色（bgJ），导致一个完整的和选择性的损害自然发生的杀伤淋巴细胞，而所有其他形式的细胞介导的裂解显然是正常的。有缺陷的基因产物可能位于肿瘤细胞接触后的裂解途径内。由于许多细胞类型，包括自然杀伤（NK）细胞，T细胞和巨噬细胞，可能参与体内肿瘤耐药性1，这些小鼠将提供一个关键的假设测试，它是NK细胞提供了第一道防线，对肿瘤2。这种突变体对于肿瘤免疫学的进一步研究可能是非常宝贵的，正如裸鼠在评估胸腺在T淋巴系统发育中的作用和T细胞在肿瘤排斥中的作用中是不可或缺的一样。
GERM LINE mutations affecting defined cell populations are often valuable tools in elucidating the function of these cells in complex biological systems such as tumour rejection. We report here that a mutant gene in the mouse called beige (bgJ), leads to a complete and selective impairment of naturally occurring killer lymphocytes, whereas all other forms of cell-mediated lysis are apparently normal. The defective gene product may lie within the lytic pathway subsequent to tumour cell contact. Because many cell types, including natural killer (NK) cells, T cells and macrophages, may be involved in tumour resistance in vivo1, these mice will provide a critical test of the hypothesis that it is NK cells which provide a first line of defence against neoplasia2. It is likely that this mutant will be invaluable for further investigations in tumour immunology just as the nude mouse has been indispensable in evaluating the role of thethymus in the development of the T-lymphoid system and the role of T cells in the rejection of tumours.