Quantitative effects of male age on sperm motion
Quantitative effects of male age on sperm motion
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DOI：
10.1093/humrep/del250
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发表时间：
2006-11-01
影响因子：
6.1
通讯作者：
Wyrobek, A. J.
中科院分区：
文献类型：
--
作者：
Sloter, E.;Schmid, T. E.;Wyrobek, A. J.
背景技术背景：精液质量与生育状况相关，但影响精液质量的风险因素的定量信息很少，特别是在非临床人群中。男性年龄的增长与精液质量的下降有关，其中对精子活力的影响最大。然而，很少有关于精子运动受男性年龄影响的具体组成部分的定量数据。方法：我们对90名年龄在22-80岁之间、无不育或生殖问题病史的非临床队列的非吸烟男性进行了计算机辅助精液分析（CASA）测量的14个方面的精液质量进行了线性回归分析。研究结果：我们发现CASA测定的运动性与年龄相关的下降（运动性%，每年0.8%;进行性运动%，每年0.9%;快速运动%，每年0.4%，P
BACKGROUND: Semen quality is associated with fertility status, but there is little quantitative information on risk factors that affect semen quality, especially in non-clinical populations. Advancing male age has been associated with a decline in semen quality, with the largest effect being on sperm motility. However, there is little quantitative data on the specific components of sperm motion that are affected by male age. METHODS: We performed linear regression analyses of 14 aspects of semen quality measured by computer-assisted semen analysis (CASA) in a non-clinical cohort of 90 non-smoking men, aged 22-80 years, who had no history of infertility or reproductive problems. RESULTS: We found age-associated declines in CASA-determined motility (% motile, 0.8% per year; % progressively motile, 0.9% per year; % rapidly motile, 0.4% per year, P