Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.
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DOI：
10.1093/nar/gkw377
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发表时间：
2016-07-08
影响因子：
14.9
通讯作者：
Ma'ayan A
中科院分区：
文献类型：
--
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
富集分析是分析全基因组实验产生的基因集的常用方法。在这里，我们提出了一个重要的更新，在这个领域的工具之一，称为Enrichr。Enrichr目前包含大量不同的基因组文库，可供分析和下载。总的来说，Enrichr目前包含来自102个基因集文库的180 184个注释基因集。Enrichr增加了新的功能，包括提交模糊集、上传BED文件、改进的应用程序编程接口以及将结果可视化为聚类图。总的来说，Enrichr是一个综合性的资源，为策划基因集和搜索引擎，积累生物学知识，为进一步的生物学发现。Enrichr可在http://amp.pharm.mssm.edu/Enrichr免费获得。
Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at: http://amp.pharm.mssm.edu/Enrichr.