Short Telomeres, but Not Telomere Attrition Rates, Are Associated With Carotid Atherosclerosis.
Short Telomeres, but Not Telomere Attrition Rates, Are Associated With Carotid Atherosclerosis.
复制标题
DOI：
10.1161/hypertensionaha.117.09354
复制
发表时间：
2017-08
期刊：
影响因子：
--
通讯作者：
Benetos A
中科院分区：
文献类型：
--
作者：
Toupance S;Labat C;Temmar M;Rossignol P;Kimura M;Aviv A;Benetos A
短端粒与动脉粥样硬化有关。然而，动脉粥样硬化和端粒长度之间的时间关系尚不清楚。这项工作的目的是研究颈动脉粥样硬化斑块的时间形成和进展与端粒动力学的关系。在一项纵向研究中，包括154名法国男性和女性（基线年龄31-76岁），颈动脉斑块通过回声描记术定量，白细胞端粒长度通过Southern印迹法在基线和随访检查时测量。在9.5年的随访期内，在基线和随访检查时有斑块的个体中端粒磨损率没有差异（23.3 ± 2.0 bp/年）比随访期间出现斑块的个体（26.5 ± 2.0 bp/年）和基线或随访检查时无斑块的患者（22.5 ± 2.3 bp/年，p = 0.79）。基线时，端粒长度与颈动脉斑块的存在（p = 0.02）和斑块区域的数量（p = 0.005）相关。观察到年龄和斑块存在之间的相互作用（p = 0.03），使得斑块和端粒长度之间的关联在年轻时更明显。总之，在9.5年的随访期内，颈动脉粥样硬化与端粒磨损增加无关。短端粒长度与早发性颈动脉粥样硬化的相关性大于晚发性颈动脉粥样硬化。我们的研究结果支持了这样的论点，即成年期端粒磨损的增加可能不能解释动脉粥样硬化疾病受试者中观察到的短端粒。相反，短端粒先于疾病的临床表现。
Short telomeres are associated with atherosclerosis. However, the temporal relation between atherosclerosis and telomere length is unclear. The objective of this work was to examine the temporal formation and progression of carotid atherosclerotic plaques in relation to telomere dynamics. In a longitudinal study, comprising 154 French men and women (aged 31–76 years at baseline), carotid plaques were quantified by echography and telomere length on leucocytes was measured by Southern blots at baseline and follow-up examinations. Telomere attrition rates during the 9.5-year follow-up period were not different in individuals with plaques at both baseline and follow-up examinations (23.3 ± 2.0 bp/year) than in individuals who developed plaques during the follow-up period (26.5 ± 2.0 bp/year) and those without plaques at either baseline or follow-up examinations (22.5 ± 2.3 bp/year, p = 0.79). At baseline, telomere length was associated with presence of carotid plaques (p = 0.02) and with the number of regions with plaques (p = 0.005). An interaction (p = 0.03) between age and the presence of plaques was observed, such that the association between plaques and telomere length was more pronounced at a younger age. In conclusion, carotid atherosclerosis is not associated with increased telomere attrition over a 9.5 years follow-up period. Short telomere length is more strongly associated with early-onset than late-onset carotid atherosclerosis. Our results support the thesis that heightened telomere attrition during adult life might not explain the short telomeres observed in subjects with atherosclerotic disease. Rather, short telomeres antecedes the clinical manifestation of the disease.