Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine.
Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine.
复制标题
促肾上腺皮质激素释放激素缺乏揭示了肾上腺素的促炎作用。
DOI：
10.1073/pnas.96.12.7093
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发表时间：
1999
影响因子：
11.1
通讯作者：
Majzoub,JA
中科院分区：
文献类型：
--
作者：
Karalis,KP;Kontopoulos,E;Muglia,LJ;Majzoub,JA
Traditionally, the adrenal gland has been considered an important endocrine component of the pathway to inhibit acute inflammation via hypothalamic corticotropin-releasing hormone (CRH)-mediated secretion of glucocorticoid. Immunoreactive CRH found in inflamed tissues is a potent proinflammatory factor. Using genetic and pharmacological models of CRH deficiency, we now show that CRH deficiency unmasks a major proinflammatory effect of epinephrine secreted from the adrenal medulla. Together, epinephrine and peripheral CRH stimulate inflammation, and glucocorticoid acts as a counterbalancing force in this regard. Our findings suggest that stimulation of the acute inflammatory response should be included with the other “fight-or-flight” actions of epinephrine.
