Demystifying the role of mitochondria in senescence
Demystifying the role of mitochondria in senescence
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DOI：
10.1080/23723556.2016.1162896
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发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Passos, Joao F.
中科院分区：
文献类型：
--
作者：
Correia-Melo, Clara;Passos, Joao F.
In a study published in The EMBO Journal, we demonstrated that mitochondria are necessary for the proinflammatory phenotype of senescence. Furthermore, we identified a new senescence-regulatory pathway involving mTOR-dependent mitochondrial biogenesis. These data highlight mitochondria as targets for interventions that counteract the pro-aging effects of senescence while preserving tumor suppression.
