Natural exposure to Alternaria spores induces allergic rhinitis symptoms in sensitized children
Natural exposure to Alternaria spores induces allergic rhinitis symptoms in sensitized children
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DOI：
10.1034/j.1399-3038.2003.00031.x
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发表时间：
2003-04-01
影响因子：
4.4
通讯作者：
Marks, G
中科院分区：
文献类型：
--
作者：
Andersson, M;Downs, S;Marks, G
过敏性鼻炎与暴露于吸入性过敏原有关。对真菌链格孢属的过敏性致敏是常见的，特别是在温暖的气候中，但对链格孢属的致敏在鼻炎产生中的相关性尚未阐明。本研究的目的是确定是否自然暴露于链格孢菌诱导鼻结膜炎症状的链格孢菌致敏的儿童。1998年夏季和冬季，使用父母填写的问卷对澳大利亚内陆新南威尔士州132名特应性（皮肤点刺试验测量）儿童（7-12岁）的鼻结膜炎症状进行了测量。在整个研究期间，使用Burkard容量陷阱测量空气中的链格孢孢子和草花粉的浓度。采用Wilcoxon配对符号秩和检验和广义估计方程研究了空气中链格孢孢子浓度与鼻结膜炎症状之间的关系。在空气中链格孢属浓度高的夏季，报告鼻炎症状的链格孢属特应性儿童的比例显著高于空气中链格孢属浓度低的冬季（夜间鼻部症状为66.2% vs. 38.2%，p = 0.0001，白天鼻部症状为70.6% vs. 51.52%，p = 0.02）。夏季使用抗过敏治疗的儿童比例也高于冬季（鼻用抗过敏药物39.7% vs. 17.7%，p = 0.0003）。草花粉和链格孢菌的空气浓度之间存在很强的相关性（R = 0.94，p < 0.001）。然而，当所有对黑麦草过敏的儿童被排除在分析之外时，症状和季节之间的显着关联仍然存在。我们的结论是，接触链格孢孢子可能是过敏性鼻结膜炎的一个重要原因。
Allergic rhinitis is associated with exposure to inhaled allergens. Allergic sensitization to the fungus Alternaria is common, especially in warm climates, but the relevance of sensitization to Alternaria in the generation of rhinitis has not been elucidated. The aim of this study was to determine whether natural exposure to Alternaria induces rhinoconjuctivitis symptoms in Alternaria -sensitized children. Symptoms of rhinoconjuctivitis in 132 atopic (measured by skin prick tests) children (aged 7-12 years) in inland New South Wales Australia were measured using parent-completed questionnaires in summer and winter 1998. Airborne concentrations of Alternaria spores and grass pollen were measured throughout the study period using a Burkard volumetric trap. The relation between airborne concentrations of Alternaria spores and symptoms of rhinoconjunctivitis was examined using Wilcoxon's matched pairs signed ranked test and generalized estimating equations. The proportion of children atopic to Alternaria reporting symptoms of rhinitis was significantly higher in the summer, when airborne concentrations of Alternaria were high, than in the winter, when airborne concentrations were low (66.2% vs. 38.2% for nasal symptoms at night, p = 0.0001, 70.6% vs. 51.52% for nasal symptoms during the day, p = 0.02). The proportion of children using anti-allergic treatment was also higher in summer than in winter (anti-allergic medication for the nose 39.7% vs. 17.7%, p = 0.0003). A strong correlation between airborne concentrations of grass pollen and Alternaria was found (R = 0.94, p < 0.001). However, when all children atopic to ryegrass were excluded from the analyses, significant associations between symptoms and season remained. We conclude that exposure to Alternaria spores may be an important cause of allergic rhinoconjunctivitis.