Social Meets Molecular: Combining Phylogenetic and Latent Class Analyses to Understand HIV-1 Transmission in Switzerland
Social Meets Molecular: Combining Phylogenetic and Latent Class Analyses to Understand HIV-1 Transmission in Switzerland
复制标题
DOI：
10.1093/aje/kwu076
复制
发表时间：
2014-06-15
影响因子：
5
通讯作者：
Spycher, Ben D.
中科院分区：
文献类型：
--
作者：
Avila, Dorita;Keiser, Olivia;Spycher, Ben D.
瑞士有一种复杂的人体免疫缺陷病毒（艾滋病毒）流行病，涉及若干人口。我们在一项国家队列研究中检查了1型HIV （HIV-1）的传播。在2000年至2011年瑞士HIV队列研究中，使用潜在类别分析来确定6027名患者的社会经济和行为群体。对4013例患者的序列数据进行系统发育分析，以确定传播集群。通过相关分析和多重对应分析评估社会行为群体和传播集群之间的一致性。B亚型感染2696例，C亚型感染203例，A亚型感染196例，重组亚型感染733例（主要为CRF02_AG和CRF01_AE）。潜在分类分析确定了8组患者。大多数B亚型传播聚集在男同性恋群体（1-3组）或异性恋群体“社会经济地位较低的异性恋者”（4组）和“注射吸毒者”（8组）之间。将同性恋和异性恋群体联系起来的集群与“领取福利的老年异性恋和同性恋者”（第5组）有关。“有异性伴侣的移民妇女”（第6组）和“靠福利生活的异性移民”（第7组）与第4组和第5组共享非b类。结合社会流行病学和分子流行病学的方法可以提供对HIV-1传播的见解，并为预防策略的设计提供信息。
Switzerland has a complex human immunodeficiency virus (HIV) epidemic involving several populations. We examined transmission of HIV type 1 (HIV-1) in a national cohort study. Latent class analysis was used to identify socioeconomic and behavioral groups among 6,027 patients enrolled in the Swiss HIV Cohort Study between 2000 and 2011. Phylogenetic analysis of sequence data, available for 4,013 patients, was used to identify transmission clusters. Concordance between sociobehavioral groups and transmission clusters was assessed in correlation and multiple correspondence analyses. A total of 2,696 patients were infected with subtype B, 203 with subtype C, 196 with subtype A, and 733 with recombinant subtypes (mainly CRF02_AG and CRF01_AE). Latent class analysis identified 8 patient groups. Most transmission clusters of subtype B were shared between groups of gay men (groups 1-3) or between the heterosexual groups "heterosexual people of lower socioeconomic position" (group 4) and "injection drug users" (group 8). Clusters linking homosexual and heterosexual groups were associated with "older heterosexual and gay people on welfare" (group 5). "Migrant women in heterosexual partnerships" (group 6) and "heterosexual migrants on welfare" (group 7) shared non-B clusters with groups 4 and 5. Combining approaches from social and molecular epidemiology can provide insights into HIV-1 transmission and inform the design of prevention strategies.