Control of hormone receptor levels and growth of 7,12-dimethylbenz(a)anthracene-induced mammary tumors by estrogens, progesterone and prolactin.
Control of hormone receptor levels and growth of 7,12-dimethylbenz(a)anthracene-induced mammary tumors by estrogens, progesterone and prolactin.
复制标题
通过雌激素、黄体酮和催乳素控制激素受体水平和 7,12-二甲基苯并（a）蒽诱导的乳腺肿瘤的生长。
作者：
J. Asselin;P. Kelly;M. Caron;F. Labrie
研究了各种激素治疗对二甲基苯并蒽（DMBA）诱导的大鼠乳腺肿瘤生长和激素受体水平的影响。在卵巢切除术后5周半的肿瘤中测量的雌二醇-17 β（E2）（0.6 ± 0.2 pmol/g组织）、R 5020（0.9 ± 0.4 pmol/g组织）和催乳素（PRL）（特异性结合的0.9 ± 0.4%）的激素结合较低。在未阉割动物中，E2、R 5020和PRL的结合值分别为2.9 ± 0.4 pmol/g组织、13.7 ± 2.0 pmol/g组织和3.2 ± 0.3%。对去势动物单独给予孕酮（P）（0.5 mg/天）三周对肿瘤大小或激素结合没有影响。用E2（0.5 μg/天）治疗相同时间段增加肿瘤大小和激素结合：E2，3.0 ± 0.7 pmol/g组织; R 5020，14.8 ± 3.3 pmol/g组织; PRL，2.4 ± 0.6%。在每日剂量为2 mg时，单独使用PRL可使肿瘤大小略有增加，而与雌酮的结合仍保持稳定。
The effect of various hormone treatments was investigated on the growth and hormone receptor levels of hormone-dependent (those which regressed after ovariectomy) dimethylbenz- (a)anthracene (DMBA)-induced mammary tumors in the rat. Hormone binding measured in die tumors which remained 5½ weeks after ovariectomy was low for estradiol-17β (E2) (0.6 ± 0.2 pmol/g tissue), R 5020 (0.9 ± 0.4 pmol/g tissue) and prolactin (PRL) (0.9 ± 0.4% of specific binding). In non-castrated animals, binding values were 2.9 ± 0.4 pmol/g tissue, 13.7 ± 2.0 pmol/g tissue and 3.2 ± 0.3% for E2, R 5020 and PRL, respectively. Administration of progesterone (P) alone (0.5 mg/day) for three weeks to castrated animals had no effect on tumor size or hormone binding. Treatment with E2 (0.5 μg/day) for the same period of time increased tumor size and hormone binding: E2, 3.0 ± 0.7 pmol/g tissue; R 5020, 14.8 ± 3.3 pmol/g tissue; PRL, 2.4 ± 0.6%. At a daily dose of 2 mg, PRL alone increased tumor size slightly while honnone binding remai...