Protective Effect of Dietary Lily Bulb on Dextran Sulfate Sodium-Induced Colitis in Rats Fed a High-Fat Diet.
Protective Effect of Dietary Lily Bulb on Dextran Sulfate Sodium-Induced Colitis in Rats Fed a High-Fat Diet.
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膳食百合对高脂饮食大鼠右旋糖酐硫酸钠诱发的结肠炎的保护作用。
DOI：
10.3177/jnsv.62.206
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发表时间：
2016
影响因子：
1.6
通讯作者：
N. Kato
中科院分区：
文献类型：
--
作者：
Y. Okazaki;H. Chiji;N. Kato
东亚地区传统上食用百合球茎，其中含有大量的葡甘露聚糖。本研究调查了膳食百合球茎对高脂 (HF) 饮食大鼠葡聚糖硫酸钠 (DSS) 诱导的结肠炎的影响。雄性 Sprague-Dawley 大鼠饲喂含 30% 牛脂、加或不加 7% 蒸百合粉的饮食 17 d。在最后 7 天内用 DSS 代替饮用水诱发实验性结肠炎。第17天，百合+DSS组的疾病活动指数（DAI）显着低于DSS组。与对照组相比，DSS组粪便双歧杆菌丰度显着降低，但摄入百合后又恢复了。 DSS 组的盲肠丁酸、粪便粘蛋白和碱性磷酸酶 (ALP) 活性显着高于对照组。饮食中的百合球茎可增强 DSS 处理引起的盲肠丁酸、粪便粘蛋白和 ALP 活性的增加。这些结果表明，百合球茎通过调节 HF 饮食喂养的大鼠的结肠微生物群、有机酸、粘蛋白和 ALP 活性来减轻 DSS 诱导的结肠炎。
Lily bulb is traditionally consumed in East Asia and contains high amounts of glucomannan. This study investigated the effect of dietary lily bulb on dextran sulfate sodium (DSS)-induced colitis in rats fed a high-fat (HF) diet. Male Sprague-Dawley rats were fed a diet containing 30% beef tallow with or without 7% steamed lily bulb powder for 17 d. Experimental colitis was induced by replacing drinking water with DSS during the last 7 d. The disease activity index (DAI) was significantly lower in the lily bulb+DSS group than in the DSS group on day 17. The fecal abundance of Bifidobacterium was significantly reduced in the DSS group compared with that in the control group, but it was recovered by lily bulb intake. Cecal butyrate, fecal mucins, and alkaline phosphatase (ALP) activity were significantly higher in the DSS group than in the control group. Dietary lily bulb potentiated the increase in cecal butyrate, fecal mucins, and the ALP activity caused by DSS treatment. These results indicate that lily bulb attenuates DSS-induced colitis by modulating colonic microflora, organic acids, mucins, and ALP activity in HF diet-fed rats.