The isolation and characterization of murine macrophages.
The isolation and characterization of murine macrophages.
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DOI：
10.1002/0471142735.im1401s83
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发表时间：
2008-11
影响因子：
--
通讯作者：
Mosser, David M
中科院分区：
文献类型：
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作者：
Zhang, Xia;Goncalves, Ricardo;Mosser, David M
巨噬细胞是单核吞噬细胞，广泛分布于全身。这些细胞可促进发育和体内平衡，并参与固有免疫和适应性免疫应答。巨噬细胞的生理机能可因它们所处的环境以及所接触的局部刺激而有极大差异。巨噬细胞是分泌能力很强的细胞，在此作用下，它们能够促进和调节免疫应答，并导致自身免疫性病理状况。巨噬细胞具有高度的吞噬能力，长期以来一直被认为是重要的免疫效应细胞。由于巨噬细胞在宿主防御中起着至关重要的作用，其在维持体内平衡以及促进组织重塑和伤口愈合方面的重要作用有时被忽视。
Macrophages are mononuclear phagocytes that are widely distributed throughout the body. These cells can contribute to development and homeostasis and participate in innate and adaptive immune responses. The physiology of macrophages can vary tremendously depending on the environment in which they reside and the local stimuli to which they are exposed. Macrophages are prodigious secretory cells, and in that role can promote and regulate immune responses and contribute to autoimmune pathologies. Macrophages are highly phagocytic, and in this capacity have long been considered to be essential immune effector cells. The important roles of macrophages in maintaining homeostasis and in contributing to tissue remodeling and wound healing is sometimes overlooked because of their vital role in host defense.