mTORC1 signaling governs hematopoietic stem cell quiescence.
mTORC1 signaling governs hematopoietic stem cell quiescence.
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DOI：
10.4161/cc.8.7.8045
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发表时间：
2009-04-01
期刊：
影响因子：
--
通讯作者：
DePinho RA
中科院分区：
文献类型：
--
作者：
Gan B;DePinho RA
The stringent regulation of hematopoietic stem cell (HSC) quiescence versus cell cycle progression is essential for the preservation of a pool of long-term self-renewing cells and vital for sustaining an adequate supply of all blood lineages throughout life. Cell growth, the process that is mass increase, serves as a trigger for cell cycle progression and is regulated predominantly by mammalian target of rapamycin complex 1 (mTORC1) signaling. Emerging data from various mice models show deletion of several mTORC1 negative regulators, including PTEN, TSC1, PML and Fbxw7 result in similar HSC phenotypes characterized as HSC hyper-proliferation and subsequent exhaustion, and defective repopulating potential. Further pharmacological approaches show that PTEN, TSC1 and PML regulate HSC maintenance through mTORC1. mTORC1-mediated cell growth regulatory circuits thus plays a critical role in the regulation of HSC quiescence.
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DOI：
10.1084/jem.20081297
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen C;Liu Y;Liu R;Ikenoue T;Guan KL;Liu Y;Zheng P
通讯作者：
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影响因子：
64.8
作者：
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64.8
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Morrison, Sean J.
影响因子：
64.5
作者：
Tothova, Zuzana;Kollipara, Ramya;Gilliland, D. Gary
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影响因子：
21.3
作者：
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通讯作者：
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