The first report of multidrug resistance in gastrointestinal nematodes in goat population in Poland
The first report of multidrug resistance in gastrointestinal nematodes in goat population in Poland
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DOI：
10.1186/s12917-020-02501-5
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发表时间：
2020-08-03
影响因子：
2.6
通讯作者：
Kaba, Jaroslaw
中科院分区：
文献类型：
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作者：
Mickiewicz, Marcin;Czopowicz, Michal;Kaba, Jaroslaw
背景用三种基本类型的驱虫药（苯并咪唑类、大环内酯类和咪唑并噻唑类）之一进行预防性驱虫治疗仍然是全世界控制小反刍动物胃肠道线虫感染的主要手段。因此，抗蠕虫药耐药性严重威胁着小反刍动物的健康和生产。虽然大多数国家已经报告了对一类驱虫药的耐药性，但新出现的问题是对两种甚至所有类别的耐药性，称为多药耐药性。本研究旨在证明胃肠道线虫在山羊在波兰.ResultsThe一个在体内的方法（粪便虫卵计数减少试验）和两个在体外的方法（卵孵化试验和幼虫发育试验）在两个山羊在南部波兰牛群进行的组合存在的多重耐药性的胃肠道线虫耐芬苯达唑和伊维菌素在两个牛群。此外，在一个牛群中，它揭示了对最后一种有效驱虫剂左旋咪唑的耐药性的发展，以应对一年的密集使用。捻转血矛线虫是最普遍的胃肠道线虫的样品中，苯并咪唑类和伊维菌素的耐药性被发现，而Trichostrongylus colubriformis占主导地位时，左旋咪唑observed.ConclusionThis研究首次表明，多重耐药性的胃肠道线虫的三个基本类的驱虫剂已经存在于山羊种群在波兰。此外，这可能表明不同种或属的胃肠道线虫对特定驱虫剂的耐药性。
BackgroundProphylactic anthelmintic treatment with one of three basic classes of anthelmintics (benzimidazoles, macrocyclic lactones and imidazothiazoles) is still the mainstay of control of gastrointestinal nematode infections in small ruminants worldwide. As a consequence, anthelmintic resistance is a serious threat to small ruminant health and production. While the resistance to one class of anthelmintics has already been reported in most of countries, the newly-emerging problem is the resistance to two or even all of classes referred to as multidrug resistance. This study aimed to evidence the presence of multidrug resistance of gastrointestinal nematodes in goats in Poland.ResultsThe combination of one in vivo method (fecal egg count reduction test) and two in vitro methods (egg hatch test and larval development test) performed in two goat herds in the southern Poland showed the presence of gastrointestinal nematodes resistant to fenbendazole and ivermectin in both herds. Moreover, in one herd it revealed the development of resistance to the last effective anthelmintic, levamisole, in response to one-year intensive use. Haemonchus contortus was the most prevalent gastrointestinal nematode in samples in which resistance to benzimidazoles and ivermectin was found, whereas Trichostrongylus colubriformis predominated when resistance to levamisole was observed.ConclusionThis study shows for the first time that multidrug resistance of gastrointestinal nematodes to three basic classes of anthelmintics is already present in goat population in Poland. Moreover, it may indicate that different species or genera of gastrointestinal nematodes are responsible for the resistance to specific anthelmintics.