Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men
Cold-Induced Brown Adipose Tissue Activity Alters Plasma Fatty Acids and Improves Glucose Metabolism in Men
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DOI：
10.1210/jc.2017-01250
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发表时间：
2017-11-01
影响因子：
5.8
通讯作者：
Schmid, Sebastian M.
中科院分区：
文献类型：
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作者：
Iwen, K. Alexander;Backhaus, Jenny;Schmid, Sebastian M.
背景：越来越多的证据表明棕色脂肪组织（BAT）激活对人体葡萄糖和脂质代谢的有益作用。目前尚不清楚冷诱导的BAT激活是否不仅影响胰岛素敏感性，还影响胰岛素分泌。同样，在清除循环脂肪酸（FAs）的作用还没有得到充分explored.Objective：探索冷诱导的BAT激活对胰岛素敏感性和分泌的影响，以及血浆FA profiles.Design：15名健康男性参加了交叉平衡重复内受试者研究与两个实验条件。受试者暴露于热中性（22摄氏度）和中度寒冷（18.06摄氏度，颤抖除外）通过使用水灌注全身服。在志愿者的一个子集中，通过[F-18]-氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描来量化冷诱导的BAT激活。应用Botnia钳夹程序测定胰腺第一时相胰岛素反应（FPIR）和胰岛素敏感性。激素和代谢产物，包括26个特定的血浆FAs，在整个实验中取样。血浆去甲肾上腺素和多巴胺浓度增加，冷。外周葡萄糖摄取和胰岛素敏感性显著改善，接近20%，而FPIR保持稳定。乳蜡酸（C24：0）浓度增加，而水平的二十烷酸（C20：1 n9），神经酸（C24：1 n9），和山嵛酸（C22：0）decreased.Conclusions：冷暴露诱导交感神经系统的活动和BAT代谢在人类，导致改善葡萄糖代谢，而不影响胰腺胰岛素分泌。此外，BAT激活与不同FA的循环浓度改变相关。这些数据支持这样的概念，即人类BAT代谢以协调的方式显著促进全身葡萄糖和脂质利用。
Context: Mounting evidence suggests beneficial effects of brown adipose tissue (BAT) activation on glucose and lipid metabolism in humans. It is unclear whether cold-induced BAT activation affects not only insulin sensitivity but also insulin secretion. Likewise, the role in clearing circulating fatty acids (FAs) has not been fully explored.Objective: Exploring the effects of cold-induced BAT activation on insulin sensitivity and secretion, as well as on plasma FA profiles.Design: Fifteen healthy men participated in a cross-balanced repeated within-subject study with two experimental conditions. Subjects were exposed to thermoneutrality (22 degrees C) and to moderate cold (18.06 degrees C, shivering excluded) by use of a water-perfused whole body suit. Cold-induced BAT activation was quantified by [F-18]-fluorodeoxyglucose positron emission tomography-computed tomography in a subset of volunteers. A Botnia clamp procedure was applied to determine pancreatic first phase insulin response (FPIR) and insulin sensitivity. Hormones and metabolites, including 26 specific plasma FAs, were sampled throughout the experiment.Results: Cold exposure induced BAT activity. Plasma noradrenaline and dopamine concentrations increased in response to cold. Peripheral glucose uptake and insulin sensitivity significantly improved by similar to 20%, whereas FPIR remained stable. Lignoceric acid (C24:0) concentrations increased, whereas levels of eicosanoic acid (C20:1n9), nervonic acid (C24:1n9), and behenic acid (C22:0) decreased.Conclusions: Cold-exposure induces sympathetic nervous system activity and BAT metabolism in humans, resulting in improved glucose metabolism without affecting pancreatic insulin secretion. In addition, BAT activation is associated with altered circulating concentrations of distinct FAs. These data support the concept that human BAT metabolism significantly contributes to whole body glucose and lipid utilization in a coordinated manner.