Incidence and course of dementia in people with Down's syndrome: findings from a population-based study
Incidence and course of dementia in people with Down's syndrome: findings from a population-based study
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DOI：
10.1046/j.1365-2788.2000.00263.x
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发表时间：
2000-04-01
影响因子：
3.6
通讯作者：
Stevens, F
中科院分区：
文献类型：
--
作者：
Holland, AJ;Hon, J;Stevens, F
唐氏综合症（DS）患者的阿尔茨海默病（AD）患病率随着年龄的增长而显著增加。然而。痴呆的早期临床表现、病程和发病率的性质尚不确定。本研究的目的是调查年龄在30岁及以上处于痴呆风险年龄的DS患者的年龄相关临床变化和痴呆发病率的特征。在一次类似的评估后18个月，使用剑桥老年人精神障碍检查的修改版本来确定记忆、个性、一般心理功能和日常生活技能变化的程度和性质。在第一次评估时，最初报告的变化主要是在行为和个性上。在第二次评估中，额叶样痴呆的总体估计发病率很高（0.24），主要发生在年轻人群中，伴有AD的发病率。同时符合ICD-10和DSM-IV标准，0.04，主要在老年人群中。目前的作者假设，观察到的人格变化和年轻人群中额叶样痴呆的高发病率可能表明，在退行性痴呆患者中，随着阿尔茨海默样神经病理的进展，额叶的功能首先受到损害。
The prevalence rate of Alzheimer's disease (AD) in people with Down's syndrome (DS) increases significantly with age. However. the nature of the early clinical presentation, course and incidence rates of dementia are uncertain. The aims of the present study were to investigate the characteristics of age-related clinical changes and incidence rates for dementia in a population-based sample of people with DS aged 30 years and older at the age of risk for dementia. A modified version of the Cambridge Examination for Mental Disorders of the Elderly informant inter-view was used to determine the extent and nature of changes in memory, personality, general mental functioning and daily living skill 18 months after a similar assessment At the time of the firn assessment, the initial changes reported were predominately in behaviour and personality. At the second assessment, overall estimated incidence rates for frontal-like dementia were high (0.24), mainly in the younger groups, with incidence rates of AD. meeting both ICD-10 and DSM-IV criteria, of 0.04 predominately in the older groups. The present authors have hypothesized that the observed personality changes and the high estimated incidence rates of frontal-like dementia in the younger groups may indicate that functions served by the frontal lobes are the first to be compromised with the progressive development of Alzheimer-like neuropathology in people with DS.