Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery
Prognostic significance of circulating IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery
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DOI：
10.1006/clim.2001.5163
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发表时间：
2002-02-01
影响因子：
8.6
通讯作者：
De Vita, F
中科院分区：
文献类型：
--
作者：
Galizia, G;Orditura, M;De Vita, F
本文探讨了结肠癌患者手术前后血清IL-10和IL-6水平的变化及其与预后的关系。为此，50名结肠癌手术候选患者被纳入研究。其中30人可能会接受潜在的治愈性手术。采用ELISA法检测术前、术后不同时间点血清细胞因子水平。发现癌症患者中IL-10和IL-6的循环水平相对于对照升高。IL-10和IL-6血清水平均被证明可预测根治性手术的可能性（预测准确性，83.3%）。除6例接受根治性手术的患者外，所有患者的IL-10血清水平均恢复正常。后者有肿瘤复发（预测准确率为100%）。与此相反，IL-6血清水平显着下降，在所有患者中，无论是否治愈手术实现，但没有正常化。在多变量分析中，发现基础IL-10血清水平是显著预测无病生存率的变量之一。逐步回归选择肿瘤分期、基础IL-10血清水平和基础CEA血清水平作为预测肿瘤复发可能性的最佳变量组合。总之，术前血清IL-10水平被证明是预测进行根治性手术的可能性以及与术后第16天IL-10血清水平结合预测肿瘤复发的有用标志物（预测准确度分别为73.6%和96%）。发现IL-6血清水平具有更有限的预后作用。(C)2002 Elsevier Science（美国）。
The prognostic significance of IL-10 and IL-6 serum levels in colon cancer patients undergoing surgery was investigated. To this end, 50 candidate patients with colon cancer for surgery were admitted to the study. Of these, 30 could be subjected to a potentially curative surgery. Cytokine serum levels at several time points before and after surgery were measured by ELISA. Circulating levels of IL-10 and IL-6 were found to be elevated in cancer patients with respect to controls. Both IL-10 and IL-6 serum levels were demonstrated to predict the likelihood of curative surgery (predictive accuracy, 83.3%). IL-10 serum levels returned to normal in all but 6 patients who underwent curative surgery. These latter had tumor recurrence (predictive accuracy, 100%). In contrast, IL-6 serum levels significantly decreased in all patients, regardless of whether cure was surgically achieved, but did not normalize. On multivariate analysis, basal IL-10 serum levels were found to be among the variables significantly predicting the disease-free survival rate. Stepwise regression selected tumor stage, basal IL-10 serum level, and basal CEA serum level as the best combination of variables for prediction of the likelihood of tumor recurrence. In conclusion, preoperative serum levels of IL-10 were shown to be useful markers for predicting both likelihood to perform curative surgery and, in combination with the 16th postoperative day IL-10 serum levels, tumor recurrence (predictive accuracy, 73.6 and 96%, respectively). IL-6 serum levels were found to have a more limited prognostic role. (C) 2002 Elsevier Science (USA).