A microneedle roller for transdermal drug delivery
A microneedle roller for transdermal drug delivery
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DOI：
10.1016/j.ejpb.2010.07.001
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发表时间：
2010-10-01
影响因子：
4.9
通讯作者：
Prausnitz, Mark R.
中科院分区：
文献类型：
--
作者：
Park, Jung-Hwan;Choi, Seong-O;Prausnitz, Mark R.
微针滚筒已被用于治疗用于美容目的的大面积皮肤，并用于增加药物输送的皮肤渗透性。在这项研究中，我们介绍了一种由微模塑疏水性聚乳酸和亲水性羧甲基纤维素复制而成的倾斜旋转紫外光刻聚合物微针滚筒。这些微针在人和猪的身体皮肤上制造了微米级的洞，允许乙酰水杨酸进入。台盼蓝和直径分别为50 nm和200 nm的纳米颗粒。乙酰水杨酸的释放量随着皮肤上打孔的数量增加而增加，比未经处理的皮肤大1-2个数量级。微针在孔间皮肤中的横向扩散符合预期的扩散动力学，有效扩散系数值比水中的扩散系数小23-160倍。与在扁平贴片上插入微针相比，在全厚猪皮上逐行顺序插入微针所需的插入力较小。总体而言，由复制的聚合物薄膜制备的聚合物微针滚筒提供了一种简单的方法来增加药物输送的皮肤渗透性。(C)2010爱思唯尔B.V.保留所有权利。
Microneedle rollers have been used to treat large areas of skin for cosmetic purposes and to increase skin permeability for drug delivery. In this study, we introduce a polymer microneedle roller fabricated by inclined rotational UV lithography, replicated by micromolding hydrophobic polylactic acid and hydrophilic carboxy-methyl-cellulose. These microneedles created micron-scale holes in human and porcine cadaver skin that permitted entry of acetylsalicylic acid. Trypan blue and nanoparticles measuring 50 nm and 200 nm in diameter. The amount of acetylsalicylic acid delivered increased with the number of holes made in the skin and was 1-2 orders of magnitude greater than in untreated skin. Lateral diffusion in the skin between holes made by microneedles followed expected diffusional kinetics, with effective diffusivity values that were 23-160 times smaller than in water. Compared to inserting microneedles on a flat patch, the sequential insertion of microneedles row by row on a roller required less insertion force in full-thickness porcine skin. Overall, polymer microneedle rollers, prepared from replicated polymer films, offer a simple way to increase skin permeability for drug delivery. (C) 2010 Elsevier B.V. All rights reserved.